肝胆经经络推拿治疗卵泡黄素化不破裂综合征的效果观察

Effect of manipulation along the liver and bladder meridians on luteinized unruptured follicle syndrome

目的探究肝胆经经络推拿治疗卵泡黄素化不破裂综合征的临床效果。方法抽取2019年1月至2020年12月于郑州大学第二附属医院就诊的120例卵泡黄素化不破裂综合征患者作为研究对象,按照随机数字表法将其分为对照组与研究组,每组60例。对照组给予人绒毛膜促性腺激素注射治疗,研究组在对照组基础上给予肝胆经经络推拿治疗。比较两组患者的临床疗效、血清性激素水平、治疗前后中医证候评分、卵泡发育情况、排卵率与妊娠率。结果研究组治疗后总有效率(83.33%,59/60)高于对照组(65.00%,39/60),P<0.05。研究组卵泡成熟当天黄体生成素、雌二醇水平均高于对照组(P均<0.05)。两组患者治疗后各中医证候评分均低于治疗前(P均<0.05),且治疗后研究组各中医证候评分均低于对照组(P均<0.05)。研究组患者优势卵泡长径、成熟卵泡子宫内膜厚度均大于对照组,卵泡成熟时间短于对照组(P<0.05);研究组患者排卵率(68.33%,41/60)与妊娠率(33.33%,20/60)均高于对照组(50.00%,30/60;16.67%,10/60),P均<0.05。结论肝胆经经络推拿治疗卵泡黄素化不破裂综合征有助于调节患者体内性激素水平,促进卵泡发育,提高患者的排卵率与妊娠率。

Objective To investigate the clinical effect of manipulation along the liver and bladder meridians in the treatment of luteinized unruptured follicle syndrome.Methods A total of 120 patients with luteinized unruptured follicle syndrome admitted to the Second Affiliated Hospital of Zhengzhou University from January 2019 to December 2020 were selected as the research subjects.They were divided into control group and study group according to random number table method,with 60 patients in each group.Patients in the control group were treated with human chorionic gonadotropin(HCG)injection,while patients in the study group were given manipulation along the liver and bladder meridians based on the treatment of the control group.The curative effect,serum sex hormone levels,Traditional Chinese Medicine(TCM)syndrome scores before and after treatment,follicular development,ovulation rate and pregnancy rate were compared between the two groups.Results The total response rate in the study group(83.33%,59/60)was higher than that in the control group(65.00%,39/60),P<0.05.The levels of luteinizing hormone and estradiol in the study group were higher than those in the control group on the day of follicular maturation(P<0.05).The TCM syndrome scores of the two groups after treatment were lower than those before treatment(all P<0.05),and the TCM syndrome scores of the study group after treatment were lower than those of the control group(all P<0.05).The diameter of the dominant follicle and endometrial thickness of the study group were greater than those of the control group,and the follicle maturation time was significantly shorter than that of the control group(P<0.05).The ovulation rate and pregnancy rate in the study group were 68.33%(41/60)and 33.33%(20/60),respectively,higher than 50.00%(30/60)and 16.67%(10/60)of the control group,correspondingly,all P<0.05.Conclusions Manipulation along the liver and bladder meridians can regulate the levels of sex hormones,promote follicular development and improve the ovulation rate and pregnancy rate in patients with luteinized unruptured follicle syndrome.