丙硫氧嘧啶与甲巯咪唑治疗甲状腺功能亢进的临床疗效及药理分析

Clinical Efficacy and Pharmacological Analysis of Propylthiouracil and Methimazole in the Treatment of Hyperthyroidism

目的探讨丙硫氧嘧啶与甲巯咪唑治疗甲状腺功能亢进的临床疗效及药理分析。方法选取2018年1月至2019年1月在大连大学附属新华医院就诊的80例甲状腺功能亢进患者,随机分为试验组和对照组,对照组40例患者给予口服丙硫氧嘧啶进行治疗;试验组40例给予口服甲巯咪唑治疗,比较两组患者体内三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)及血清促甲状腺激素(TSH)水平。比较两组患者甲状腺功能亢进症评分比较、肝功能损害评分、疾病疗效评分水平、主要临床评分表现。结果试验组患者体内FT3及FT4水平显著低于对照组患者,TSH水平显著高于对照组患者(P<0.05)。试验组患者甲状腺功能亢进症评分比较、肝功能损害评分、疾病疗效评分水平、主要临床评分表现优于对照组患者(P<0.05)。结论甲巯咪唑治疗甲亢效果优于丙硫氧嘧啶,具有临床应用价值。

Objective To investigate the clinical efficacy and pharmacological analysis of propylthiouracil and methimazole in the treatment of hyperthyroidism.Methods Eighty patients with hyperthyroidism treated in Xinhua Hospital Affiliated to Dalian University from January 2018 to January 2019 were randomly divided into experimental group and control group.40 patients in the control group were treated with oral propylthiouracil;40 patients in the experimental group were treated with oral methimazole.The levels of triiodothyronine(FT3),serum free thyroxine(FT4)and serum thyroid stimulating hormone(TSH)were compared between the two groups.The hyperthyroidism score,liver function damage score,disease efficacy score and main clinical scores were compared between the two groups.Results The levels of FT3 and FT4 in the experimental group were significantly lower than those in the control group,and the level of TSH was significantly higher than those in the control group(P<0.05).The scores of hyperthyroidism,liver function damage,disease curative effect and main clinical scores in the experimental group were better than those in the control group(P<0.05).Conclusion Methimazole is better than propylthiouracil in the treatment of hyperthyroidism.