分析高血压合并糖尿病患者接受替米沙坦+卡维地洛联合治疗的降压效果及对糖代谢的影响

To analyze the antihypertensive effect of telmisartan combined with carvedilol in hypertensive patients with diabetes mellitus and its effect on glucose metabolism

目的:分析高血压合并糖尿病患者接受替米沙坦+卡维地洛联合治疗的降压效果及对糖代谢的影响。方法:2018年10月-2020年6月收治高血压合并糖尿病患者96例,随机分为两组,各48例。观察组给予替米沙坦联合卡维地洛治疗,参照组给予吲达帕胺联合卡维地洛治疗,比较两组治疗效果。结果:观察组收缩压及舒张压水平均显著低于参照组,差异有统计学意义(P<0.05);观察组餐后2 h血糖(PPG)、空腹胰岛素(FIns)及餐后2 h胰岛素(2 hFIns)水平均显著低于参照组,差异有统计学意义(P<0.05)。结论:在高血压合并糖尿病患者的治疗中联合应用替米沙坦和卡维地洛,对控制血压水平以及改善糖代谢指标水平均有非常显著的效果。

Objective:To analyze the antihypertensive effect of telmisartan combined with carvedilol in hypertensive patients with diabetes mellitus and its effect on glucose metabolism.Methods:From October 2018 to June 2020,96 patients with hypertension and diabetes were selected.They were randomly divided into two groups with 48 cases in each group.The observation group was treated with telmisartan combined with carvedilol.The control group was treated with indapamide combined with carvedilol.We compared the therapeutic effects of the two groups.Results:In the observation group,the average systolic blood pressure and diastolic blood pressure were significantly lower than those in the reference group,the difference was statistically significant(P<0.05).In the observation group,the levels of postprandial 2 h blood glucose(PPG),fasting insulin(FIns)and postprandial 2-h insulin(2 hFIns)were significantly lower than those in the reference group,the difference was statistically significant(P<0.05).Conclusion:In the treatment of hypertension complicated with diabetes mellitus,the combination of telmisartan and carvedilol has a very significant effect on controlling blood pressure and improving glucose metabolism.