分析彩色多普勒超声对早期糖尿病肾病的诊断价值及肾动脉血流阻力指数与血清超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)的相关性

To analyze the diagnostic value of color Doppler ultrasound in early diabetic nephropathy and the correlation between renal artery blood flow resistance index and serum high sensitivity C reactive protein(hs-CRP)and vascular endothelial growth factor(VEGF)

目的:分析彩色多普勒超声对早期糖尿病肾病的诊断价值及肾动脉血流阻力指数与血清超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)的相关性。方法:选取2019年4月-2020年10月早期糖尿病肾病患者30例,作为观察组;并选取同期体检健康人员30例,作为对照组。两组均接受彩色多普勒超声诊断检查及hs-CRP、VEGF水平检测,分析两组肾血流参数检出情况与hs-CRP及VEGF水平。结果:观察组肾锥体两侧叶间动脉、肾主动脉及肾段动脉的血流阻力指数均高于对照组,肾锥体两侧叶间动脉、肾主动脉、肾段动脉的收缩期最大流速及舒张期最低流速均低于对照组,差异均有统计学意义(P<0.05)。观察组hs-CRP及VEGF水平均高于对照组,差异有统计学意义(P<0.05)。结论:早期糖尿病肾病患者肾血流参数与正常人群存在明显差异,其hs-CRP及VEGF水平明显高于正常水平,彩色多普勒超声诊断能够准确给出患者肾血流参数信息。

Objective:To analyze the diagnostic value of color Doppler ultrasound in early diabetic nephropathy and the correlation between renal artery blood flow resistance index and serum high sensitivity C reactive protein(hs-CRP)and vascular endothelial growth factor(VEGF).Methods:From April 2019 to October 2020,30 patients with early diabetic nephropathy were selected as the observation group.30 healthy persons in the same period were selected as the control group.Both groups were examined by color Doppler ultrasound and the levels of hs-CRP and VEGF.We analyzed the detection of renal blood flow parameters and the levels of hs-CRP and VEGF in the two groups.Results:In the observation group,the blood flow resistance indexes of bilateral interlobular arteries of renal cone,renal aorta and segmental renal artery were higher than those in the control group,and the maximum systolic velocity and minimum diastolic velocity of bilateral interlobular arteries of renal cone,renal aorta and segmental renal artery were lower than those in the control group,the difference was statistically significant(P<0.05).The levels of hs-CRP and VEGF in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The renal blood flow parameters of patients with early diabetic nephropathy are significantly different from those of the normal population,the levels of hs-CRP and VEGF are significantly higher than the normal level,Color Doppler ultrasound diagnosis can accurately give the information of renal blood flow parameters.