乳腺癌组织中PD-L1、IMP3表达水平与患者临床病理学特征、术后复发的关系

Relationship among the expression levels of PD-L1 and IMP3 in breast cancer tissues,the clinicopathological characteristics of patients and postoperative recurrence

目的分析程序性死亡受体-配体1(PD-L1)、胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)在乳腺癌组织中的表达情况,探究其与患者临床病理学特征、术后复发的关系。方法回顾性分析2015年1月至2021年3月吉安市妇幼保健院和吉安市中心人民医院收治的102例乳腺浸润性癌患者的临床资料,收集患者癌组织病理标本,采用SP法免疫组织化学染色检测病理组织PD-L1、IMP3表达情况,分析PD-L1、IMP3表达水平与患者临床病理学特征、术后复发的关系。结果102例乳腺癌病理组织标本中PD-L1、IMP3的阳性表达率分别为57.84%、19.61%;IMP3在不同分子分型乳腺癌患者病理组织中的阳性表达率从高到低依次为Basal-like型(66.67%)、Luminal B型[人表皮生长因子受体-2(HER-2)阳性](17.24%)、HER-2过表达型(15.38%)、Luminal A型(14.29%)、Luminal B型(HER-2阴性)(10.00%)(均P<0.05);且合并坏死的乳腺癌组织中IMP3阳性表达率(33.33%)显著高于未合并坏死者(14.67%)(P<0.05);随着乳腺癌患者术后复发风险级别的逐渐升高,乳腺癌组织中PD-L1、IMP3阳性表达率逐渐升高,但组间比较,差异均无统计学意义(均P>0.05);经Spearman等级相关分析显示,乳腺癌组织中PD-L1与IMP3阳性表达呈正相关性(r=0.172),但差异无统计学意义(P>0.05)。结论乳腺癌病理组织PD-L1、IMP3水平呈高表达,尤其在三阴性乳腺癌病理组织中表达水平最高,且IPM3阳性表达及其表达水平变化与乳腺肿瘤患者的不良预后和进展有关,而PD-L1的阳性表达及其表达变化与肿瘤的不良预后和进展无关,且两者间阳性表达亦无明显相关性。

Objective Analyzed the expression of programmed death receptor-ligand 1(PD-L1),insulin-like growth factorⅡmRNA binding protein 3(IMP3)in breast cancer tissues,explored the relationship among them and patients’clinicopathological characteristics and postoperative recurrence.Methods Retrospectively analysed the clinical datas of 102 patients with invasive breast cancer admitted to the department of pathology of Ji’an Maternal and Child Health Hospital and Ji’an Central People’s Hospital from January 2015 to March 2021,the pathological specimens of cancer tissues from patients were collected,and the expression of PD-L1 and IMP3 in pathological tissues were detected used by SP immunohistochemical staining method,the relationship among the PD-L1 and IMP3 expression levels,clinicopathological characteristics and postoperative recurrence of patients.Results The positive expression rates of PD-L1 and IMP3 among 102 cases breast cancer pathological tissue specimens were 57.84%and 19.61%respectively;the the positive expression rate of IMP3 in the pathological tissues of breast cancer patients with different molecular types from high to low were Basal-like(66.67%),Luminal B type[Human epidermal growth factor receptor-2(HER-2)positive](17.24%),HER-2 overexpression type(15.38%),Luminal type A(14.29%),Luminal B type(HER-2 negative)(10.00%)in order(all P<0.05);and the positive expression rate of IMP3 in breast cancer tissues with necrosis(33.33%)was significantly higher than that in those without necrosis(14.67%)(P<0.05);with the gradual increase in the risk of recurrence in breast cancer patients after surgery,the positive expression rate of PD-L1 and IMP3 in breast cancer tissues gradually increased,but comparing between groups,the difference was without statistical significance(all P>0.05);Spearman rank correlation analysis showed that,there was a positive correlation between the positive expression of PD-L1 and IMP3 in breast cancer tissues(r=0.172),but difference was without statistical significance(P>0.05).Conclusion The levels of PD-L1 and IMP3 in breast cancer pathological tissues are highly expressed,especially in the pathological tissues of triple-negative breast cancer,the expression level is highest,and the positive expression of IPM3 and the expression level changes are related to the poor prognosis and progression of breast cancer patients,while the positive expression of PD-L1 and the expression level changes are not related to the poor prognosis and progression of breast cancer patients,and there is no obvious correlation between the positive expression of PD-L1 and IPM3.