从调节中央生物钟的角度探讨针刺治疗昼夜节律睡眠觉醒障碍的作用机制

Discussion on the mechanism of acupuncture treatment for circadian rhythm sleep-wake disorders from the perspective of regulating central biological clock

现代社会中昼夜节律睡眠觉醒障碍这一类睡眠疾病随着人们生活作息模式的转变而日益凸显,昼夜节律紊乱所引起的睡眠问题以及对人体健康的危害正受到越来越广泛的重视。针刺疗法在许多研究中均显示出对睡眠相关昼夜节律的调节作用。文章从现代研究中针刺对中央生物钟的调控、对睡眠相关昼夜节律的调节以及针刺的授时特性角度进行分析,旨在探讨针刺对睡眠相关昼夜节律的调节效应和潜在机制,提出了针刺效应的生物学基础和生理学作用,是基于对中央生物钟基因、相关信号分子以及神经递质的水平产生影响,进而有效调节睡眠-觉醒节律、褪黑素节律和体温节律这一研究思路,拟为今后针刺治疗昼夜节律睡眠觉醒障碍提供新的思路与方法。

As people’s daily life patterns change in modern society,circadian rhythm sleep-wake disorders have been more and more prominent.More and more attention has been paid to the sleep problems caused by circadian disruption and its harm to human health.Acupuncture has been shown to regulate sleep-related circadian rhythms in many studies.In this paper,we analyzed the acupuncture’s role in regulating central biological clock and sleep-related circadian rhythm,and its temporal feature from recent studies,aiming to discuss the effect of acupuncture on sleep-related circadian rhythm and its unrevealed mechanism.We also proposed that acupuncture may regulate the sleep-wake cycle,melatonin rhythm and body temperature rhythm by affecting the central circadian clock gene,related signaling molecules and neurotransmitter levels,intended to provide new ideas and methods for acupuncture treatment of circadian rhythm sleep arousal disorder in the future.