代谢综合征与骨关节炎关系的研究进展

Research progress on the relationship between metabolic syndrome and osteoarthritis

一、骨关节炎(osteoarthritis,OA)与代谢综合征的概述OA的主要症状是疼痛,据估计全球患病人数超过2.5亿,每年对于该病的医疗支出超过1850亿美元[1]。中老年人多发,最常见的发病部位是膝关节,其次是手部和髋关节,女性的发病率高于男性[2]。Wallace等[3]通过研究大量美国成人遗骸后发现,OA的发病率自20世纪中期以来增加超过2倍,然而,有证据表明,寿命延长可能不是OA发病率升高的惟一原因,与多数疾病一样,OA的发病机制涉及基因和环境之间的相互作用,从某些层面上来说,OA也符合生物学家所谓的"错配疾病"(mismatch disease)的概念,例如人们生活质量的提高以及现代化生活方式的改变所致的肥胖症的流行是OA公认的一个危险因素。

Osteoarthritis(OA)is a multi-factorial degenerative joint disease,which mainly involves changes in articular cartilage,subchondral bone,ligaments,joint capsule,synovium and surrounding structures of joints.Its mechanism of occurrence and development is still not clear.With the aging of the social population in China,the incidence of OA is gradually increasing.At the same time,most elderly patients are associated with basic metabolic diseases such as hypertension and diabetes.Metabolic osteoarthritis has now been characterized as a new subtype of OA.In addition to surgery,palliative treatment is preferred but with limited effect.So that,metabolic osteoarthritis brings a heavy burden to society and individuals,especially elderly patients.This article mainly describes the current research status of the relationship between metabolic syndrome and osteoarthritis,and provides references for exploration of related targeted therapies.