同步推量调强放疗治疗鼻咽癌的效果及预后观察

Observation on Therapeutic Effect and Prognosis of Simultaneous Intensity Modulated Radiotherapy in the Treatment of Nasopharyngeal Carcinoma

目的探讨同步推量调强放疗对鼻咽癌患者治疗效果及预后的影响。方法回顾性分析60例鼻咽癌患者临床资料,根据治疗方法不同分为对照组(30例)与观察组(30例)。观察组采用同步推量调强放疗,对照组采用常规放疗。比较2组治疗效果、免疫功能、预后情况及不良反应。结果2组治疗总有效率、近期生存率、复发率对比,差异无统计学意义(P>0.05)。2组治疗后免疫功能均降低,但观察组免疫功能指标水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率(3.33%)低于对照组(26.67%),差异有统计学意义(P<0.05)。结论鼻咽癌患者采用同步推量调强放疗治疗的效果与常规放疗效果相当,中期预后情况相近,但同步推量调强放疗对患者免疫功能影响更小,安全性更高。

Objective To investigate the effect of simultaneous intensity modulated radiotherapy on the treatment effect and prognosis of patients with nasopharyngeal carcinoma.Methods Clinical data of 60 patients with nasopharyngeal carcinoma were retrospectively analyzed.According to different treatment methods,they were divided into the control group(30 cases)and the observation group(30 cases).Synchronous intensity modulated radiotherapy was used in the observation group,and conventional radiotherapy was used in the control group.The treatment effect,immune function,prognosis and adverse reaction were compared between the 2 groups.Results There was no statistically significant difference in the total effective rate,short-term survival rate and recurrence rate between the 2 groups(P>0.05);After treatment,the immune function of the 2 groups decreased,but the level of immune function index in the observation group was higher than that of the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions during treatment in the observation group(3.33%)was lower than that of the control group(26.67%),the difference was statistically significant(P<0.05).Conclusion For patients with nasopharyngeal carcinoma,the effect of simultaneous intensity modulated radiotherapy is equivalent to that of conventional radiotherapy,and the mid-term prognosis is similar.However,synchronous intensity modulated radiotherapy has smaller influence on the immune function of patients and higher safety.