腕踝针联合阿片类药物治疗肝癌癌痛的疗效观察

Efficacy Observation of Wrist-ankle Acupuncture Combined with Opioids for Primary Liver Cancer-related Pain

目的观察腕踝针联合阿片类药物治疗原发性肝癌(PHC)癌痛的临床疗效。方法将80例PHC患者随机分为联合组和药物组,每组40例。药物组按照“三阶梯”止痛法给予阿片类药物治疗,联合组在药物组基础上给予腕踝针治疗。比较两组治疗前后疼痛强度评分和血清P物质(SP)含量,并比较两组临床疗效和不良反应发生率。结果联合组治疗后疼痛缓解率(62.5%)优于药物组(40.0%)(P<0.05)。两组治疗前疼痛强度评分比较差异无统计学意义(P>0.05);两组治疗后疼痛强度评分明显降低(P<0.05),联合组低于药物组(P<0.05)。两组治疗前血清SP含量比较差异无统计学意义(P>0.05);两组治疗后血清SP含量明显降低(P<0.05),联合组低于药物组(P<0.05)。联合组不良反应发生率(17.5%)低于药物组(37.5%)(P<0.05)。结论采用腕踝针联合阿片类药物治疗PHC癌痛效果满意,可有效缓解患者疼痛,降低SP含量,减少因药物引起不良反应,安全性高。

Objective To observe the clinical efficacy of wrist-ankle acupuncture plus opioids in treating primary liver cancer-related pain.Method Eighty patients with primary liver cancer-related pain were randomized into a joint group and a medication group,with 40 cases in each group.The medication group was offered opioids according to the three-step analgesic ladder method,while the joint group was given additional wrist-ankle acupuncture.The pain intensity score and the content of serum substance P(SP)were compared before and after treatment.The clinical efficacy and adverse reaction rate were also compared.Result After treatment,the pain relief rate in the joint group(62.5%)was more significant than that in the medication group(40.0%),(P<0.05).There was no significant difference in the pain intensity score prior to treatment between the two groups(P>0.05);the pain intensity score dropped notably in both groups after treatment(P<0.05),and was lower in the joint group than in the medication group(P<0.05).There was no significant difference in the content of serum SP between the two groups before treatment(P>0.05);the content of serum SP declined notably in both groups after treatment(P<0.05),and was lower in the joint group than in the medication group(P<0.05).The rate of adverse reaction was lower in the joint group(17.5%)than in the medication group(37.5%),(P<0.05).Conclusion Wrist-ankle acupuncture plus opioids can produce content efficacy in treating primary liver cancer-related pain;this approach can effectively relieve pain,down-regulate the content of SP and reduce medication-induced adverse reactions,with high safety rating.