纳洛酮联合依达拉奉对急性脑出血患者认知功能的影响分析

Effect of naloxone combined with edaravone on cognitive function in patients with acute cerebral hemorrhage

目的研究纳洛酮联合依达拉奉对急性脑出血患者认知功能的影响。方法选取2019年4月至2020年4月南阳市中心医院收治的200例急性脑出血患者作为研究对象,根据治疗方式的不同分为对照组和观察组,每组100例。对照组采用手术治疗,观察组采用纳洛酮联合依达拉奉治疗。比较两组治疗后临床疗效、认知功能及血浆纤维蛋白原(FIB)、D-二聚体(D-D)水平。结果观察组治疗后临床疗效高于对照组(P<0.05)。两组治疗前NIHSS评分、Fugl-Meyer评分比较,差异无统计学意义(P>0.05)。观察组治疗后NIHSS评分、Fugl-Meyer评分优于对照组(P<0.05)。两组治疗前血浆FIB、D-D水平比较,差异无统计学意义(P>0.05)。观察组治疗后FIB、D-D水平优于对照组(P<0.05)。结论纳洛酮联合依达拉奉可提高急性脑出血患者疗效,改善认知功能,降低炎症反应。

【Objective】 To study the effect of naloxone combined with edaravone on cognitive function in patients with acute cerebral hemorrhage.【Methods】 Two hundred patients with acute intracerebral hemorrhage admitted to our hospital from April2019 to April 2020 were divided into 2 groups with 100 cases in each group.The control group was treated with surgery,and the observation group was treated with naloxone combined with edaravone.Clinical efficacy,cognitive function,plasma fibrinogen(FIB) and D-dimer(D-D) levels were compared between the two groups.【Results】 The total effective rate of the observation group was 95.00%,which was higher than 83.00% of the control group.Compared with before treatment,NIHSS score and D-D level in two groups decreased after treatment,and the observation group was lower than the control group;Fugl-Meyer score and FIB level increased,and the observation group was higher than the control group(all P<0.05).【Conclusion】 Naloxone combined with edaravone can enhance the efficacy,improve cognitive function and reduce inflammatory response in patients with acute cerebral hemorrhage.