HIF-1α在慢性肾脏病中的研究进展

Progress of research on HIF-1αin chronic kidney disease

低氧反应与慢性肾脏病(CKD)密切相关,低氧诱导因子(HIF)是机体适应低氧反应的主要调节因子。HIF-1α是HIF的氧敏感性亚基,在CKD发生和发展过程中发挥重要作用。本文就HIF-1α与CKD的炎症、贫血及矿物质与骨异常等的相关性研究作一总结,为进一步研究提供依据。

Hypoxia response is closely related to chronic kidney disease(CKD).Hypoxia-inducible factor(HIF)is the main regulator of the body′s adaptation to hypoxia.HIF-1αis an oxygen-sensitive subunit of HIF,and plays an important role in the occurrence and development of CKD.This article summarized the researches on the correlation between HIF-1αand CKD′s inflammation,anemia,or mineral and bone disorders,etc,in order to provide basis for further study.