高压氧联合常规药物治疗冠心病心绞痛疗效的Meta分析

Meta-analysis of the efficacy of hyperbaric oxygen combined with conventional drugs in treating angina pectoris of coronary heart disease

目的采用Meta分析方法系统评价高压氧联合常规药物治疗冠心病心绞痛的疗效。方法检索Cochrane Library、Medline、Embase、万方、维普、中国知网数据库,时间限定为自建库至2020年10月。收集高压氧联合常规药物治疗冠心病心绞痛的临床随机对照试验(RCTs)。3名研究者独立筛选收集到的RCTs,提取相关数据、评估试验质量。应用RevMan 5.4软件进行Meta分析。结果本研究共纳入11个RCTs。Meta分析结果显示,高压氧组在临床总有效性、减轻患者症状、改善心电图表现方面均优于对照组。结论高压氧联合常规药物可更好地减轻冠心病心绞痛患者的症状,改善心电图表现。

Objective To systematically evaluate the efficacy of hyperbaric oxygen(HBO)combined with comentional drugs in the treatment of angina pectoris caused by coronary heart disease with meta-analysis.Methods The data on clinical randomized controlled trials(RCTs)of HBO combined with conventional drugs in the treatment of angina pectoris due to coronary heart disease in Cochrane Library,Medline,Embase,Wanfang Data,Cqvip,China National Knowledge Infrastructure(CNKI)were collected,and the time period was from the respective founding day of the above databases to October 2020.Three researchers independently screened the collected RCTs,extracted relevant data,and evaluated the quality of the trials.RevMan 5.4 software was used for meta-analysis.Results A total of 11 RCTs were included in this study.Meta-analysis results showed that the HBO group was better than the control group in terms of total clinical effectiveness,alleviation of angina symptoms,and improvement in ECG performance.Conclusion HBO combined with conventional drugs can better alleviate the symptoms of angina pectoris due to coronary heart disease and improve their ECG performance.In the future,high-quality RCTs need to be carried out to verify the conclusion of this study.