肠道菌群在癫痫治疗中的作用研究进展

Progress on role of intestinal flora in the treatment of epilepsy

癫痫作为神经系统的常见疾病,大多数儿童癫痫经药物治疗能控制,但仍有20%~30%癫痫患儿经治疗后控制效果不佳,最终发展为难治性癫痫,严重影响其健康成长。近年来研究发现肠道菌群通过脑-肠轴与大脑产生双向联系,包括迷走神经、神经内分泌下丘脑-垂体-肾上腺轴、肠道免疫系统、神经递质及神经调节因子等,对大脑的生理、行为和认知功能具有显著影响,从而在癫痫的发生发展中发挥作用。肠道菌群与癫痫的密切联系,可能作为治疗癫痫的一个靶点,本文就肠道菌群在癫痫治疗中的潜在作用展开综述。

Epilepsy is one of the common diseases of nervous system.Most children′s epilepsy can be controlled by drug treatment,but 20%—30%of children with epilepsy still have poor control effect after treatment,and eventually develop into intractable epilepsy,which seriously affects their healthy growth.In recent years,it has been found that the intestinal flora has two-way connection with the brain through the brain-intestine axis,including vagus nerve,neuroendocrine hypothalamic-pituitary-adrenal axis,intestinal immune system,neurotransmitters and neuroregulatory factors,which have a significant impact on the physiological,behavioral and cognitive functions of the brain,thus playing a role in the occurrence and development of epilepsy.Intestinal flora is closely related to epilepsy and may be a target for epilepsy treatment.Therefore,this review summarized the potential role of intestinal flora in epilepsy treatment.