普伐他汀防治子痫前期的有效性及安全性的研究进展

Progress on pravastatin and its safety in prevention and treatment of preeclampsia

子痫前期是造成母胎预后不良的主要原因。一系列的细胞、动物实验及少量临床研究发现,普伐他汀可通过调节血管生成、上调血红素氧合酶的表达以及刺激一氧化氮的生成来防治子痫前期,且未观察到妊娠中晚期应用的不良影响。本文综述普伐他汀防治子痫前期的机制、效果及其安全性的最新研究进展。

Preeclampsia is the main cause of poor maternal-fetal outcomes.A series of cell and animal experiments,and a small number of clinical studies have shown that pravastatin can prevent and treat preeclampsia by regulating angiogenesis,increasing the expression of heme oxygenase,and stimulating the production of nitric oxide without any reported adverse effects during pregnancy.We review the latest progress on the mechanism,effect,and safety of pravastatin in the prevention and treatment of preeclampsia.