期刊文献+

Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy 被引量:14

原文传递
导出
摘要 Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy.
出处 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2021年第10期2983-2994,共12页 药学学报(英文版)
基金 supported in part by a grant from National Natural Science Foundation of China(81802255) Shanghai Pujiang Program(17PJD036,China) a grant from Shanghai Municipal Commission of Health and Family Planning Program(20174Y0131,China) National Key Research&Development Project(2016YFC0902300,China) major disease clinical skills enhancement program of three year action plan for promoting clinical skills and clinical innovation in municipal hospitals Shanghai Shen Kang Hospital Development Center Clinical Research Plan of SHDC(16CR1001A,China) “Dream Tutor”Outstanding Young Talents Program(fkyq1901,China) key disciplines of Shanghai Pulmonary Hospital(2017ZZ02012,China) grant of Shanghai Science and Technology Commission(16JC1405900,China)。
  • 相关文献

参考文献2

二级参考文献3

共引文献26

同被引文献35

引证文献14

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部