丹红注射液辅助西医疗法治疗冠心病心律失常临床研究

Clinical Study on Danhong Injection Assisting Western Medicine for Arrhythmia Due to Coronary Heart Disease

目的:观察丹红注射液辅助西医疗法治疗冠心病心律失常的临床疗效及对心电图、血流动力学参数的影响。方法:将102例冠心病心律失常患者随机分为观察组52例和对照组50例。对照组给予常规西医治疗,观察组在对照组基础上给予丹红注射液治疗。观察2组治疗前后心电图指标(QRS时限、QT间期、PR间期、室性早搏次数及短阵室速次数)、血流动力学参数[全血低切黏度(WBLSV)、全血高切黏度(WBHSV)、红细胞沉降率(ESR)、红细胞比容(HCT)及纤维蛋白原(Fg)]变化,并评价2组临床疗效和不良反应情况。结果:观察组总有效率为94.23%,高于对照组80.00%,差异有统计学意义(P<0.05)。治疗前,2组QRS时限、QT间期、PR间期、室性早搏次数、短阵室速次数比较,差异无统计学意义(P>0.05)。治疗后,2组室性早搏次数、短阵室速次数低于治疗前,QRS时限、QT间期及PR间期较治疗前延长(P<0.05);且观察组治疗后室性早搏次数、短阵室速次数均低于对照组,QRS时限、QT间期及PR间期长于对照组(P<0.05)。治疗前,2组WBLSV、WBHSV、ESR、HCT、Fg水平比较,差异无统计学意义(P>0.05)。治疗后,2组WBLSV、WBHSV、ESR、HCT、Fg水平低于治疗前(P<0.05);且观察组WBLSV、WBHSV、ESR、HCT、Fg水平均低于对照组(P<0.05)。观察组不良反应发生率为3.85%,低于对照组16.00%,差异有统计学意义(P<0.05)。结论:丹红注射液辅助西医疗法治疗冠心病心律失常临床疗效确切,能改善心电图指标及血流动力学参数,降低不良反应发生率。

Objective:To observe the clinical effect of Danhong injection assisting western medicine for arrhythmia due to coronary heart disease and its effect on electrocardiogram and hemodynamic parameters.Methods:A total of 102 cases of patients with arrhythmia due to coronary heart disease were randomly divided into the observation group and the control group,52 and 50 cases in each group respectively.The control group was given routine western medicine treatment,and the observation group was additionally given Danhong injection based on the treatment of the control group.The changes in the electrocardiogram indexes including QRS time limit,QT interval,PR interval,frequency of ventricular premature beat and frequency of non-sustained ventricular tachycardia as well as the hemodynamic parameters including whole blood low shear viscosity(WBLSV),whole blood high shear viscosity(WBHSV),erythrocyte sedimentation rate(ESR),hematocrit(HCT)and fibrinogen(Fg)before and after treatment in the two groups were observed.Clinical effects and adverse reactions in the two groups were evaluated.Results:The total effective rate was 94.23%in the observation group,higher than that of80.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of QRS time limit,QT interval,PR interval,frequency of ventricular premature beat and frequency of non-sustained ventricular tachycardia between the two groups(P>0.05).After treatment,the frequency of ventricular premature beat and the frequency of non-sustained ventricular tachycardia in the two groups were lower than those before treatment,and QRS time limit,QT interval and PR interval were lengthened when compared with those before treatment(P<0.05);the frequency of ventricular premature beat and the frequency of non-sustained ventricular tachycardia in the observation group were lower than those in the control group,and QRS time limit,QT interval and PR interval were longer(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of WBLSV,WBHSV,ESR,HCT and Fg between the two groups(P>0.05).After treatment,the levels of WBLSV,WBHSV,ESR,HCT and Fg in the two groups were lower than those before treatment(P<0.05);the levels of WBLSV,WBHSV、ESR,HCT and Fg in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 3.85%in the observation group,lower than that of 16.00%in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Danhong injection assisting western medicine has a definite clinical effect in treating arrhythmia due to coronary heart disease,which can improve electrocardiogram indexes and hemodynamic parameters,and reduce the incidence of adverse reactions.