丹参川芎嗪注射液辅助常规西药治疗急性缺血性脑卒中临床研究

Clinical Study on Danshen Chuanxiongqin Injection Assisting Routine Western Medicine for Acute Ischemic Stroke

目的:观察丹参川芎嗪注射液辅助常规西药治疗急性缺血性脑卒中(AIS)的临床疗效。方法:选取AIS患者60例,按随机数字表法分为观察组和对照组各30例。对照组给予常规西药治疗,观察组在对照组基础上给予丹参川芎嗪注射液辅助治疗,均连续治疗28 d。比较2组治疗前后中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分、肢体运动功能评测法(FMA)评分、改良Barthel指数(MBI)评定量表评分和炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏-C反应蛋白(hs-CRP)]水平,并评估2组临床治疗效果。结果:观察组总有效率为96.67%,明显高于对照组70.00%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分、NIHSS评分较治疗前明显降低(P<0.05),且观察组中医证候积分、NIHSS评分明显低于对照组(P<0.05)。治疗后,2组FMA评分、MBI评分高于治疗前,观察组FMA评分、MBI评分高于对照组(P<0.05)。治疗后,2组hs-CRP、IL-6、TNF-α水平低于治疗前,观察组hs-CRP、IL-6、TNF-α水平均低于对照组(P<0.05)。结论:丹参川芎嗪注射液辅助常规西药治疗AIS疗效显著,可减轻患者临床症状,改善神经功能缺损程度及肢体活动能力,提高患者日常生活活动能力,减轻机体炎症反应。

Objective:To observe the clinical effect of Danshen Chuanxiongqin injection assisting routine western medicine for acute ischemic stroke(AIS).Methods:A total of 60 cases of AIS patients were divided into the observation group and the control group according to the random number table method,30 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Danshen Chuanxiongqin injection based on the treatment of the control group.Both groups were treated for 28 days.Before and after treatment,the scores of Chinese medicine syndromes,National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer Assessment(FMA)and Modified Barthel Index(MBI)as well as the levels of inflammatory factors including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C-reactive protein(hs-CRP)in the two groups were compared.The clinical effect in the two groups were evaluated.Results:The total effective rate was 96.67%in the observation group,significantly higher than that of 70.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of Chinese medicine syndromes and NIHSS in the two groups were significantly decreased when compared with those before treatment(P<0.05),and the scores of Chinese medicine syndromes and NIHSS in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the scores of FMA and MBI in the two groups were higher than those before treatment,and the scores of FMA and MBI in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of hs-CRP,IL-6 and TNF-αin the two groups were lower than those before treatment,and the levels of hs-CRP,IL-6 and TNF-αin the observation group were lower than those in the control group(P<0.05).Conclusion:Danshen Chuanxiongqin injection assisting routine western medicine has a significant curative effect in treating AIS,and can relieve clinical symptoms,improve neurologic impairment,limb activity and activities of daily living,and reduce inflammatory responses in the body.