中药熏洗联合玻璃酸钠注射液治疗膝骨关节炎临床研究

Clinical Study on Chinese Herbal Fumigation Combined with Sodium Hyaluronate Injection for Knee Osteoarthritis

目的:观察中药熏洗联合玻璃酸钠注射液治疗膝骨关节炎的临床疗效及对膝关节功能的影响。方法:选取75例膝骨关节炎患者作为研究对象,按随机数字表法分为研究组38例及对照组37例,2组关节腔均注射玻璃酸钠注射液,研究组加用中药熏洗治疗,2组均治疗4周。观察2组临床疗效,比较2组治疗前、治疗第1周、治疗第4周后的肿胀度,比较2组治疗前后西安大略和麦克马斯特大学骨关节炎指数评分(WOMAC)量表。比较2组治疗前、治疗4周后血浆D-二聚体(D-dimer)、血清C-反应蛋白(CRP)及血沉(ESR)水平。结果:研究组总有效率为97.37%,对照组为86.49%,2组比较,差异有统计学意义(P<0.05)。治疗第1周、第4周后,2组肿胀度均低于治疗前;治疗第1周、治疗第4周的同一时间段,研究组肿胀度均低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,2组疼痛程度、僵硬程度、关节功能受损评分及总分均较治疗前下降,研究组上述4项评分均低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,2组D-dimer、CRP、ESR指标值均较治疗前下降,研究组上述3项指标值均低于对照组,差异均有统计学意义(P<0.05)。结论:中药熏洗联合玻璃酸钠注射液对膝骨关节炎疗效较好,能缓解膝关节疼痛、僵硬,改善膝关节功能。

Objective:To observe the clinical effect of Chinese herbal fumigation combined with sodium hyaluronate injection for knee osteoarthritis and its effect on knee joint function.Methods:A total of 75 cases of patients with knee osteoarthritis were selected as the study subjects,and were divided into the study group and the control group according to the random number table method,with 38 and 37 cases in each group respectively.Both groups were injected with sodium hyaluronate injection into articular cavity,and the study group was additionally treated with Chinese herbal fumigation.Both groups were treated for four weeks.The clinical effects in the two groups were observed.Before treatment,at the first week of treatment,and at the fourth week of treatment,the swelling degree in the two groups was compared.Before and after treatment,Western Ontario and McMaster University Osteoarthritis Index(WOMAC)scores in the two groups were compared.Before treatment and after four-week treatment,the levels of plasma D-dimer,serum C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in the two groups were compared.Results:The total effective rate was 97.37%in the study group and 86.49%in the control group,the difference being significant(P<0.05).After one and four weeks of treatment respectively,swelling degrees in the two groups were lower than those before treatment;the swelling degree in the study group was lower than that in the control group,differences being significant(P<0.05).After four-week treatment,the scores of the degree of pain,stiffness and joint dysfunction as well as the total scores in the groups were decreased when compared with those before treatment,and the above four scores in the study group were lower than those in the control group,differences being significant(P<0.05).After four-week treatment,the values of D-dimer,CRP and ESR in the two groups were decreased when compared with those before treatment,and the values of the above three indexes in the study group were lower than those in the control group,differences being significant(P<0.05).Conclusion:Chinese herbal fumigation combined with sodium hyaluronate injection has a good curative effect in treating knee osteoarthritis,which can relieve the pain and stiffness of knee joints and improve knee joint function.