摘要
果胶主要是由α-1,4-D-半乳糖醛酸单元组成的杂多糖,侧基由不同的中性糖残基通过至少22种糖苷键连接而成。果胶具有的抗肿瘤及调节血压、血脂和血糖等生理活性,为其在药物递送载体中的研究提供了条件。首先,从羟基反应、羧基反应、羟基和羧基的非共价反应3个方面归纳了果胶的改性;其次,介绍了果胶基前药;再次,总结了化学改性、物理改性在果胶基药物载体中的应用及果胶基Pickering乳液系统在药物递送中的应用;最后,指出现阶段上述领域中存在的问题,并展望了未来的发展方向。
Pectin is a heteropolysaccharide consisted ofα-1,4-D-galactouronic acid units,whose side groups are composed of different neutral sugar residues connected by at least 22 glycosidic bonds.The physiological activities of pectin,such as anti-tumor,regulating blood pressure,blood lipid and blood glucose provide conditions for the study of pectin in drug delivery carriers.Firstly,the modification of pectin is summarized from three aspects:Hydroxyl reaction,carboxyl reaction,and non-covalent reaction of hydroxyl and carboxyl group.Subsequently,the pectin-based prodrug is introduced.Then,the application of chemical modification and physical modification in pectin-based drug carrier and the application of pectin-based Pickering emulsion system in drug delivery are summarized.Finally,the problems existing in the above mentioned fields at the present stage are pointed out,and the future development direction is prospected.
作者
李德强
张佳琪
李君
许凤
LI Deqiang;ZHANG Jiaqi;LI Jun;XU Feng(College of Chemical Engineering,Xinjiang Agricultural University,Urumchi 830052,Xinjiang,China;Beijing Key Laboratory of Lignocellulosic Chemistry,Beijing Forestry University,Beijing 100083,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2021年第11期2171-2180,共10页
Fine Chemicals
基金
新疆自治区天山英才计划第三期(2021-2023)
国家自然科学基金(21664013)
新疆自治区自然科学基金(2021D01A74)。
关键词
果胶
改性
前药
复合材料
杂化材料
皮克林乳液
药物递送载体
pectin
modification
prodrug
composite materials
hybrid materials
Pickering emulsion
drug delivery carrier
