毛细管阵列微反应器制备荧光聚合物纳米粒子

Preparation of fluorescent polymer nanoparticles based on capillary array microreactor

设计并制作了同轴毛细管阵列微反应器,以聚(9,9-二辛基芴-共-苯并噻二唑)(PFBT)为原料、四氢呋喃为溶剂、去离子水为反溶剂、聚苯乙烯-马来酸酐共聚物为稳定剂,采用纳米沉淀法制备了聚合物荧光纳米粒子。用动态光散射技术(DLS)对荧光聚合物纳米粒子的结构进行了表征。结果表明,同轴毛细管阵列微反应器中间层溶剂的存在改变了PFBT溶液与反溶剂的混合方式,克服了微流体注射纳米沉淀法中注射管口的产物沉淀堵塞问题。在PFBT质量浓度高达500 mg/L时,反应器仍可长时间持续运行。同时,聚合物纳米粒子的粒径可通过改变PFBT溶液质量浓度、溶剂和反溶剂的流量比等条件来精确调控。当PFBT溶液质量浓度为50 mg/L、去离子水与PFBT溶液流量比为750时,制备的聚合物纳米粒子尺寸可降至13 nm。该微反应器实现了聚合物纳米粒子的长时间连续可控制备。

A coaxial capillary array microreactor was designed and constructed to prepare fluorescent polymer nanoparticles by nanoprecipitation method using poly(9,9-dioctylfluorene-co-benzothiadiazole)(PFBT)was used as polymer,tetrahydrofuran as solvent,deionized water as anti-solvent and polystyrene-maleic anhydride copolymer as stabilizer.The prepared fluorescent polymer nanoparticles were characterized by dynamic light scattering(DLS).The results showed that the accumulation and blockage of products were avoided at the tip of the injection nozzle in the microreactor due to the middle solvent stream which changed the mixing process between PFBT solution and anti-solvent.The microreactor kept on running well for a long time even at the high concentration of PFBT solution of 500 mg/L.Meanwhile,the size of the nanoparticles could be adjusted precisely by varying the mass concentration of PFBT solution and the flow ratio between solvent and anti-solvent.The diameter of the prepared nanoparticles could be reduced to 13 nm under the conditions of mass concentration of PFBT solution 50 mg/L and flow ratio of deionized water to PFBT solution 750.The microreactor could realize the long-term continuous and controllable preparation of polymer nanoparticles.