帕金森病伴白日过度嗜睡的研究进展

Recent advance in Parkinson's disease with excessive daytime sleepiness

白日过度嗜睡(EDS)是帕金森病(PD)患者常见的睡眠障碍,PD患者中EDS的患病率明显高于正常人群。EDS可严重影响PD患者的生活质量,增加患者驾车时发生意外及跌倒的风险,故PD伴EDS的早期识别、及早干预非常重要。笔者现从流行病学、病因及发病机制、临床意义、影像学表现、临床评估和治疗等几个方面对近年来PD伴EDS的研究进展综述如下,以期加深临床同道对其的了解。

Excessive daytime sleepiness(EDS)is a common sleep disturbance in Parkinson's disease(PD),and the prevalence of EDS in PD patients is obviously higher than that in the normal population.EDS not only seriously influences the quality of life of PD patients but also increases the risk of accidents while driving and the risk of falling,therefore,timely recognition and intervention of EDS are of great importance.In order to deepen the understanding of EDS,this review will summarize the recent advance in epidemiology,etiology and pathogenesis,clinical significance,neuroimaging,clinical assessment,and clinical management of EDS.