抗坏血酸与抑郁症的关系

Relationship between ascorbic acid and depression

抑郁症是一种常见的情绪障碍,在世界范围内有较高的发病率和死亡率。抗坏血酸也称为维生素C,其作为一种还原性维生素在中枢神经系统中参与抗氧化、酶辅助及神经调制等过程。临床证据和动物研究均表明抗坏血酸具有抗抑郁作用。本文就抗坏血酸在中枢神经系统中的作用、目前与抑郁症关系的研究现状及可能的机制进行综述,并分析其在此疾病中的治疗意义,以期为抑郁症的临床治疗提供新的思路。

Depression is a common emotional disorder,which has high incidence rate and mortality worldwide.Ascorbic acid(AA)is also known as vitamin C.As a kind of reducing vitamin,AA participates in anti-oxidation,enzyme assistance and neuro-modulation in the central nervous system.Clinical evidence and animal studies show that AA has anti-depressant effect.This article reviews the function of AA in the nervous system,the current researches on relation between AA and depression,and possible mechanism,and analyzes its therapeutic significance in this disease,hoping to provide new ideas for the clinical treatment of depression.