我院77例严重药品不良反应报告分析

Report analysis of 77 cases of severe adverse drug reactions in our hospital

目的分析我院77例严重药品不良反应(SADR)报告,通过预警对策探讨,为临床安全用药提供参考。方法回顾性分析2015—2020年我院上报的77例SADR报告,总结其发生特点及规律。结果77例SADR报告中,以≥60岁的老年患者为主,占比45.45%。发生时间显示,用药>7 d的SADR发生频率最高。静脉用药发生SADR的比例远高于其他给药途径。抗感染药物(33.33%)、抗肿瘤药物(23.33%)发生率较高。临床表现中,全身性损害的报告最多。结论临床应注重个体化用药,加强药品不良反应(ADR)监测,为临床用药安全以及药品上市后再评价提供参考依据。

Objective To analyze the reports of 77 cases of serious adverse drug reactions(SADR)in our hospital,and to provide reference for clinical safe medication by the discussion of early warning countermeasures.Methods The reports of 77 cases of SADR reported by our hospital from 2015 to 2020 were analyzed retrospectively,and their occurrence characteristics and rules were summarized.Results Among the 77 SADR reports,elderly patients≥60 years old were the majority,accounting for 45.45%.The occurrence time showed that the frequency of SADR was the higher when the drug was used for more than 7 d.The proportion of intravenous administration of SADR was much higher than that of other administration routes.Anti-infective drugs(33.33%)and anti-tumor drugs(23.33%)had the highest incidence.Among the clinical manifestations,systemic damage was the most reported.Conclusion Clinical workers should pay attention to individualized drug use and strengthen the monitoring of adverse drug reactions(ADR),so as to provide reference basis for safety of clinical medication and post-marketing re-evaluation of drugs.