黄芪基于肠道菌群调节治疗2型糖尿病的研究进展

Research Progress of Astragalus Treatment of Type 2 Diabetes Mellitus Based on Intestinal Flora Regulation

近年来,2型糖尿病的患病率不断增加,已严重威胁人类生命健康。糖尿病的发生及发展与体内肠道菌群有密切联系,改善菌群紊乱可以一定程度降低2型糖尿病的发病率。基于肠道菌群的治疗新靶点,目前运用中药调节肠道菌群对于改善2型糖尿病具有独特和明显的优势。而中草药中的黄芪主要含有多糖、皂苷、黄酮、氨基酸等多类成分,其使用可以调节肠道菌群、增加肠道中微生物的多样性及丰富性,在治疗2型糖尿病中具有重要临床意义,有望成为防治一系列代谢性疾病的新生态学方法。

In recent years,the prevalence of type 2 diabetes mellitus has been increasing,which has seriously threatened human life and health.The occurrence and development of diabetes is closely related to the intestinal flora in the body.Improving the disorder of the flora can reduce the incidence of type 2 diabetes mellitus to a certain extent.Based on new targets for the treatment of intestinal flora,the current use of traditional Chinese medicine to regulate intestinal flora has unique and obvious advantages for improving type 2 diabetes mellitus.The astragalus in Chinese herbal medicine mainly contains polysaccharides,saponins,flavonoids,amino acids and other components,the use of which can regulate the intestinal flora and increase the diver-sity and abundance of microorganisms in the intestinal tract.It has great clinical significance in the treatment of type 2 diabetes mellitus,and is expected to become a new ecological method for the prevention and treatment of a series of metabolic diseases.