免疫炎症细胞与肺癌预后关系的研究进展

Research Progress of Immune Inflammatory Cells and Prognosis of Lung Cancer

慢性炎症反应在肺癌的发生、浸润和转移过程中起重要作用。免疫炎症细胞影响机体免疫反应,淋巴细胞减少可削弱机体抗肿瘤作用,可能促进肿瘤生长和转移。免疫炎症细胞及其复合指标有助于早期发现肿瘤,可能预测肺癌预后。由此衍生的肺癌免疫评分系统对包括肺癌在内的多种实体肿瘤的预后有预测作用,可能筛选免疫治疗优势人群,为患者预后评估、分层管理、选择治疗方案提供有力依据。目前免疫炎症细胞复合指标及评分系统的标准值范围尚不明确,还需要进一步研究确定。

Chronic inflammatory response plays an important role in the occurrence,infiltration and metastasis of lung cancer.Immune inflammatory cells affect the immune response,and lymphopenia weakens the anti-tumor effect,which may promote tumor growth and metastasis.Immune inflammatory cells and their composite indicators are helpful to the early detection of tumors and may realize the prediction of the prognosis of lung cancer.The derived lung cancer immune scoring system can predict the prognosis of a variety of solid tumors including lung cancer,and may screen the dominant population of immunotherapy,so as to provide a strong basis for the patient prognosis evaluation,hierarchical management and treatment scheme selection.The standard value range of the immune inflammatory cell complex index and scoring system is still uncertain,which needs further research.