急性肾损伤危重症患者的预后相关因素

Prognostic Factors in Critically Ill Patients with Acute Kidney Injury

急性肾损伤(AKI)是重症监护病房的常见内科疾病,患者存在发生慢性肾脏病、终末期肾病,甚至死亡的风险,目前AKI的发病率和死亡率仍较高,给社会带来沉重负担。AKI的病理生理机制尚未完全明确,患者个体差异、器官功能障碍、脓毒症等因素均可影响AKI患者的预后。虽然改善全球肾脏病预后组织指南提出了临床AKI诊治的相关标准,但对影响AKI危重症患者预后因素的认识尚未统一,深入研究AKI危重症患者的预后因素,有助于临床预防AKI并有效改善患者预后。

Acute kidney injury(AKI),as a common medical disease in intensive care units,has the risk of chronic kidney disease,end-stage renal disease,and even death.At present,the incidence and mortality of AKI are still high,which brings heavy social burden.The pathophyseologic mechanism of AKI has not been fully defined,and individual patient differences,organ dysfunction,sepsis and other factors all affect the prognosis of AKI patients.Although the global guidelines for improving prognosis of kidney disease have proposed relevant criteria for clinical diagnosis and treatment of AKI,there has not been a unified understanding of the prognostic factors affecting the prognosis of critically ill AKI patients.In-depth study on prognostic factors of critically ill AKI patients is conducive to clinical prevention of AKI and effective improvement of prognosis of AKI patients.