摘要
术后恶心呕吐(PONV)发生率为30%~80%,甲氧氯普胺是一种多巴胺D_(2)受体抑制剂,近来研究提示,甲氧氯普胺除了通过增加食管下括约肌张力和增强胃排空来降低误吸风险外,单一或联合用药可有效止吐,预防PONV发生。综合相关文献,本文将从甲氧氯普胺预防PONV的机制、优势、其他麻醉用药降低PONV发生风险临床措施方面探讨PONV的防治。
The incidence of postoperative nausea and vomiting(PONV)is 30%-80%.Metoclopramide is a dopamine D_(2) receptor inhibitor.Recent studies suggest that metoclopramide,can reduce the risk of aspiration through increasing lower esophageal sphincter tone and enhancing gastric emptying,meanwhile it can effectively prevent the occurrence of PONV by single or combined administration.Reviewing related literatures,this paper will discuss the prevention and treatment of PONV from the mechanism of metoclopramide to prevent PONV,its advantages and the administration of other anesthetic drugs.
作者
许梦君
阎文军
XU Mengjun;YAN Wenjun(Department of Anesthesology,The First Clinical Medical College of Gansu University of Chinese Medicine(Gansu Provincial Hospital),Lanzhou 730000,China)
出处
《麻醉安全与质控》
2021年第6期464-468,共5页
Perioperative Safety and Quality Assurance
基金
湖南省卫生健康委项目(20201996)。
关键词
甲氧氯普胺
术后恶心
呕吐
metoclopramide
postoperative nausea
vomiting
