左甲状腺素钠对孕中期亚临床性甲状腺功能减退症患者血清鸢尾素水平、血脂及凝血功能的影响

Effect of Levothyroxine Sodium on serum irisin level,blood lipid,and coagulation function of pregnant metaphase patients with subclinical hypothyroidism

目的研究左甲状腺素钠对孕中期亚临床性甲状腺功能减退症(SHT)患者血清鸢尾素水平、血脂及凝血功能的影响。方法选取2018年6月至2020年6月于河北北方学院附属第一医院定期接受孕期检查及围产期保健的孕中期SHT患者80例,按照随机数字表法将其分为研究组和对照组,各40例。对照组给予常规饮食指导等治疗,研究组口服左甲状腺素钠治疗,两组均治疗4周。比较治疗前后两组促甲状腺素(TSH)、游离甲状腺素(FT4)、鸢尾素、甘油三脂(TG)、总胆固醇(TC)、高密度脂肪蛋白胆固醇(HDL-C)、低密度脂肪蛋白胆固醇(LDL-C)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、纤维蛋白原。结果治疗后,研究组TSH、鸢尾素、TG、TC、LDL-C、纤维蛋白原水平低于治疗前,HDL-C高于治疗前,PT、APTT长于治疗前,且研究组TSH、鸢尾素、TG、TC、LDL-C、纤维蛋白原水平低于对照组,PT、APTT长于对照组,差异有统计学意义(P<0.05)。结论左甲状腺素钠可提高孕中期SHT患者甲状腺功能和降低血清鸢尾素水平,也一定程度地改善了患者的血脂及凝血功能。

Objective To study the effect of Levothyroxine Sodium on serum irisin level,blood lipid,and coagulation function of pregnant metaphase patients with subclinical hypothyroidism(SHT).Methods From June 2018 to June 2020,80 pregnancy patients with SHT who received regular pregnancy checkups and perinatal care at the First Affiliated Hospital of Hebei North University were selected and divided into study group and control group by the random number table method,with 40 cases in each group.The control group was given regular diet guidance and other treatments,and the study group was given oral Levothyroxine Sodium Tablets.The levels of thyroid-stimulating hormone(TSH),free thyroxine(FT4),irisin,triglycerides(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),prothrombin time(PT),activated partial thrombin time(APTT),fibrinogen were compared between the two groups before and after the treatment.Results After treatment,the levels of TSH,irisin,TG,TC,LDL-C,and fibrinogen in the study group were lower than before treatment,HDL-C was higher than before treatment,PT and APTT were longer than before treatment,and the levels of TSH,irisin,TG,TC,LDL-C,and fibrinogen in the study group were lower than those in the control group,while PT and APTT were longer than those in the control group,with statistical significances(P<0.05).Conclusion Levothyroxine Sodium can improve thyroid function and reduce serum irisin level in SHT patients during the pregnant metaphase,and also improve blood lipid and coagulation function to a certain extent.