五加减正气散治疗寒湿型小儿轮状病毒性肠炎的效果及对血清心肌酶谱、炎症因子的影响

Effect of Wujiajian Zhengqi Powder in the treatment of cold-damp type infantile rotavirus enteritis and its influence on serum myocardial enzyme spectrum and inflammatory factors

目的探讨五加减正气散治疗寒湿型小儿轮状病毒性肠炎的效果及对血清心肌酶谱、炎症因子的影响。方法选择2015年6月至2020年6月江苏省南通市中医院收治的88例寒湿型轮状病毒性肠炎患儿为研究对象,依据随机数字表法将其分为对照组(44例)和研究组(44例)。对照组采用常规西医治疗,研究组在对照组的基础上采用五加减正气散治疗,两组均持续治疗14 d。观察两组治疗前后寒湿型中医症候评分、血清肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肿瘤坏死因子-α(TNF-α)水平,比较两组临床疗效,观察两组治疗期间不良反应发生情况。结果治疗后,两组寒湿型中医症候评分、CK-MB、LDH、CK、TNF-α水平低于治疗前,且研究组低于对照组(P<0.05)。两组临床疗效比较,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论五加减正气散联合常规西医治疗寒湿型轮状病毒性肠炎患儿,疗效确切,可改善患儿的血清心肌酶谱,减轻炎症反应,安全可靠。

Objective To explore the effect of Wujiajian Zhengqi Powder in treating cold-damp type infantile rotavirus enteritis and its influence on serum myocardial enzyme spectrum and inflammatory factors.Methods Eighty-eight cold-damp type infantile rotavirus enteritis admitted to Nantong Traditional Chinese Medicine Hospital of Jiangsu Province from June 2015 to June 2020 were selected as research subjects,and they were divided into control group(44 cases)and study group(44 cases)by random number table method.The control group was treated with conventional Western medicine,and study group was treated with Wujiajian Zhengqi Powder on the basis of control group.Both groups were treated for 14 days.The scores of cold-damp type Chinese medicine symptoms,serum creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),creatine kinase(CK),and tumor necrosis factor-α(TNF-α)levels were observed,and the clinical efficacy of two groups were compared,and the occurrence of adverse reactions during the treatment of two groups were observed.Results After treatment,cold-damp type Chinese medicine syndrome scores,CK-MB,LDH,CK,and TNF-αlevels of two groups were lower than those before treatment,and study group was lower than control group(P<0.05).There was statistically significant difference in clinical efficacy between two groups(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Wujiajian Zhengqi Powder combined with conventional Western medicine in the treatment of cold-damp type infantile rotavirus enteritis has definite curative effect,which can improve the serum myocardial enzyme spectrum,reduce inflammation,and is safe and reliable.