加味苓桂术甘汤联合二甲双胍治疗痰湿内盛证肥胖型2型糖尿病的临床效果

Clinical effect of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity type 2 diabetes mellitus with phlegm-dampness syndrome

目的观察加味苓桂术甘汤联合二甲双胍治疗痰湿内盛证肥胖型2型糖尿病(T2DM)的临床疗效。方法选取2018年2月至2021年5月在广州新海医院就诊的痰湿内盛证肥胖型T2DM患者70例,用随机数字表法将其分为对照组和实验组,每组各35例。所有患者均进行健康教育和生活方式干预,对照组给予二甲双胍治疗,实验组给予加味苓桂术甘汤联合二甲双胍治疗。两组均连续治疗6周。比较两组患者治疗前后体重指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)的变化情况,评价两组临床疗效。结果治疗后,两组BMI、WHR、FPG、2hPG、HbA1c、TG、LDL-C均较治疗前降低,且实验组FPG、2hPG、HbA1c、TG、LDL-C低于对照组(P<0.05)。治疗后,实验组临床疗效优于对照组(P<0.05)。结论加味苓桂术甘汤联合二甲双胍治疗痰湿内盛证肥胖型T2DM患者的临床效果优于单纯二甲双胍治疗,在调节糖脂代谢紊乱方面有优势,值得临床推广。

Objective To observe the clinical effect of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity type 2 diabetes mellitus(T2DM)with phlegm-dampness syndrome.Methods Seventy obesity T2DM patients with phlegm-dampness syndrome in Guangzhou Xinhai Hospital from February 2018 to May 2021 were selected and divided into control group and experimental group by random number table method,with 35 cases in each group.All patients were treated with health education and lifestyle intervention.The control group were treated with Metformin,and the experimental group were treated with modified Linggui Zhugan Decoction combined with Metformin.Both groups were treated for six weeks.The changes of body mass index(BMI),waist-to-hip ratio(WHR),fasting blood glucose(FPG),2 hours postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C)in two groups were compared before and after treatment,and the clinical efficacy of the two groups was evaluated.Results After treatment,BMI,WHR,FPG,2hPG,HbA1c,TG,and LDL-C in two groups were lower than before treatment,and FPG,2hPG,HbA1c,TG,and LDL-C in the experimental group were lower than those in the control group(P<0.05).After treatment,the clinical effect of the experimental group was better than the control group(P<0.05).Conclusion The clinical efficacy of modified Linggui Zhugan Decoction combined with Metformin in the treatment of obesity T2DM patients with phlegm-dampness syndrome is superior to that of Metformin alone,and it has advantages in regulating glucolipid metabolism disorder,which is worthy of clinical promotion.