健脾清热升降方联合西药治疗反流性食管炎的效果

Effect of Jianpi Qingre Shengjiang Decoction combined with Western medicine on reflux esophagitis

目的探讨健脾清热升降方联合西药治疗反流性食管炎的效果。方法选取2019年4月至2020年7月安徽省芜湖市中医医院收治的80例反流性食管炎中虚气逆证患者,按照随机数表法分为联合组和对照组,每组40例。对照组采用常规西药治疗,联合组采用健脾清热升降方联合西药治疗,两组均治疗8周。比较两组中医症状评分、临床疗效、血清胃泌素(GAS)和血浆胃蛋白酶(PG)Ⅰ和Ⅱ水平及不良反应。结果治疗前两组中医症状评分比较,差异无统计学意义(P>0.05),治疗后两组中医症状评分均较治疗前升高,且联合组高于对照组,差异有统计学意义(P<0.05);治疗后,联合组的总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组血清GAS,血浆PGⅠ、PGⅡ水平比较,差异无统计学意义(P>0.05),治疗后两组血清GAS,血浆PGⅠ水平均较治疗前升高,且联合组高于对照组,治疗后两组血浆PGⅡ水平均较治疗前降低,且联合组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论健脾清热升降方联合西药用于治疗反流性食管炎能够改善临床症状,疗效确切,同时能够改善血清GAS和血浆PG水平,安全可靠。

Objective To investigate the effect of Jianpi Qingre Shengjiang Decoction combined with Western medicine on reflux esophagitis.Methods A total of 80 cases of reflux esophagitis patients with syndrome of qi inversion in middle deficiency admitted to Anhui Wuhu Chinese Medicine Hospital from April 2019 to July 2020 were selected and divided into combined group and control group according to random number table method,with 40 cases in each group.The control group was treated with conventional Western medicine,and the combined group was treated with Jianpi Qingre Shengjiang Decoction combined with Western medicine.Both groups were treated for eight weeks.Traditional Chinese medicine symptom score,clinical efficacy,serum gastrin(GAS)and plasma pepsin(PG)ⅠandⅡlevels and adverse reactions were compared between the two groups.Results There was no significant difference in traditional Chinese medicine symptom score between the two groups before treatment(P>0.05).After treatment,the scores of traditional Chinese medicine symptoms in both groups were higher than those before treatment,and the combined group was higher than the control group,the differences were statistically significant(P<0.05).After treatment,the total effective rate of combined group was higher than that of control group,the difference was statistically significant(P<0.05).There were no significant differences in serum GAS and plasma PGⅠand PGⅡlevels between the two groups before treatment(P>0.05).After treatment,the levels of serum GAS and plasma PGⅠin both groups were higher than those before treatment,and those in the combined group were higher than those in the control group.The levels of plasma PGⅡin both groups were lower than those before treatment,and those in the combined group were lower than those in the control group,with statistical significances(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Jianpi Qingre Shengjiang Decoction combined with Western medicine in the treatment of reflux esophagitis can improve the clinical symptoms,with definite curative effect,and improve serum GAS and plasma PG levels,which is safe and reliable.