基于数据挖掘的中医药治疗膜性肾病用药规律研究

Study on the medication law of traditional Chinese medicine in the treatment of membranous nephropathy based on data mining

目的挖掘中医药治疗膜性肾病的用药组方规律。方法以中国知网数据库收录的期刊文献为资料来源,收集并整理2000年1月至2020年9月相关中药治疗膜性肾病的文献研究。使用Excel 2013、SPSS Modeler 18.0、SPSS Statistics 21.0软件,以用药频次、性味归经及相关关联规则和聚类结果作为观察指标进行统计分析。结果通过筛选,得出处方72首,药物116种,用药频次≥10次的有26味中药,四气统计以温、寒、平为主,五味以甘、苦、辛为主,主要归肾、肺、脾以及肝经,常用中药有黄芪、茯苓、丹参、白术、当归等。高频药物聚类得到4个聚类方,体现了中医治疗膜性肾病在补益脾肾的基础上辨证运用散风通络、活血化瘀、化湿利水、清热解毒等治法。结论中医治疗膜性肾病谨遵“本虚标实”的病机本质,用药善以寒温并用、补泻兼施;重视肾肺脾三脏同调,并兼顾他脏。总结现代医家治疗膜性肾病用药特点,对临床膜性肾病的治疗具有参考意义。

Objective To explore the medication law of traditional Chinese medicine in the treatment of membranous nephropathy.Methods Periodical literatures collected by CNKI were used as data sources.The literature studies about traditional Chinese medicine in the treatment of membranous nephropathy from January 2000 to September 2020 were collected and summarized.Excel 2013,SPSS Modeler 18.0 and SPSS Statistics 21.0 software were used,and the frequency of drug use,nature and flavour,channel tropism,related association rule and clustering results were used as observation indexes for statistical analysis.Results Through screening,72 formulas and 116 kinds of herbs were obtained.Among them,26 herbs were used at least 10 times,four nature of drugs were mainly warm,cold and calm,five flavours were mainly sweet,bitter and spicy,the mainly meridians were kidney meridian,lung meridian,spleen meridian and liver meridian.Radix Astragali seu Hedysari,Poria,Radix Salviae Miltiorrhizae,Rhizoma Atractylodis Macrocephalae,Radix Angelicae Sinensis were commonly used.Four cluster formulas were obtained by high-frequency drug clustering,which showed that traditional Chinese medicine in the treatment of membranous nephropathy by using the therapies of dissipating wind and unblocking collaterals,activating blood and resolving stasis,resolving dampness and disinhibiting water,clearing heat and removing toxin,and others on the basis of tonifying spleen and kidney to syndrome differentiation.Conclusion Traditional Chinese medicine in the treatment of membranous nephropathy follows the pathogenesis nature of“root deficiency and manifestation excess”.Medications should pay attention to the application of both warming and clearing therapies,reinforcing and reducing.Kidney,lung and spleen are regulated simultaneously and paid attention,and other organs are gave consideration.The summary of the characteristics of modern doctors in the treatment of membranous nephropathy has reference significance for the clinical treatment of membranous nephropathy.