模型引导的精准用药:中国专家共识(2021版)

Model informed precision dosing:China expert consensus report

模型引导的精准用药(MIPD)是通过数学建模与模拟技术,将患者、药物和疾病等相关信息进行整合,为患者精准用药提供依据。相较于经验用药,MIPD是一种基于患者生理、病理、遗传、疾病等特征制订给药方案的新方法、可提高药物治疗的安全、有效、经济和依从性。本文对MIPD的基本原理、方法、实施和相关临床决策支持系统的应用作了论述,分析目前的现状和未来的发展方向,以期为MIPD在中国的发展和应用提供有益的参考。

Model informed precision dosing(MIPD)is a new concept to guide precision dosing for individual patient by modeling and simulation based on the available information about the individual patient,medications and the disease.Compared to the empirical dosing,MIPD could improve the efficacy,safety,economics and adherence of the pharmacotherapy according to the individual's pathophysiology,genotyping and disease progression.This consensus report provides a brief account of the concept,methodology and implementation of MIPD as well as clinical decision supporting systems for MIPD.The status and future advancing of MIPD was also discussed to facilitate the appropriate application and development of MIPD in China.