无症状高尿酸血症的诊治争议

The debate on diagnosis and treatment of asymptomatic hyperuricemia

无症状高尿酸血症患病率高,我国18~59岁居民高尿酸血症患病率约为9.8%,60岁以上老年人高尿酸血症患病率为5.5%~19.3%。无症状高尿酸血症可引起尿酸盐结晶沉积于组织从而导致慢性炎症,其与高血压、肾功能不全等疾病的发生密切相关。对无症状高尿酸血症患者的诊治目前仍存在争议。该文就无症状高尿酸血症的定义、代谢、对免疫及脏器的影响以及当前诊治争议等作一分析评价。

The prevalence of asymptomatic hyperuricemia is high.In China,the prevalence of hyperuricemia in residents aged 18-59 years is 9.8%,and that in the elderly over 60 years old is 5.5%-19.3%.Asymptomatic hyperuricemia can cause urate crystals to deposit in tissues,resulting in chronic inflammation.It is closely related to the comorbidities such as hypertension and renal insufficiency.At present,the diagnosis and treatment of asymptomatic hyperuricemia remains controversial.This paper analyzes and evaluates the definition,metabolism,effects on immunity and organs,and current controversies in diagnosis and treatment of asymptomatic hyperuricemia.