尿酸与骨代谢及骨质疏松相关机制研究进展

Research progress in the related mechanisms of uric acid and bone metabolism and osteoporosis

随着我国人口老龄化和生活方式、饮食结构的逐渐变化,骨质疏松症、高尿酸血症及痛风的患病率不断上升,且呈现年轻化趋势,已经成为我国重要的公共卫生健康问题。近年来,尿酸与骨代谢的关系逐渐引起学者的关注,已有很多研究报告对尿酸与骨代谢之间的关系及机制进行深入的探讨,在骨质疏松的发病过程中,氧化应激参与了成骨细胞和破骨细胞的调控过程,尿酸作为体内一种有效的抗氧化剂在一定程度上影响骨代谢。一些研究报告提出尿酸水平影响骨代谢,与骨质疏松具有相关性,然而也有研究显示尿酸与骨质疏松的关系受各种混杂因素影响存在不确定关系。因此,以往的研究结论仍存在争议。该文对尿酸与骨代谢及骨质疏松相关机制研究进展进行综述。

With the aging of China′s population and the gradual changes in lifestyle and diet structure,the morbidity rates of osteoporosis,hyperuricemia and gout are on the rise and showing a trend of younger age,which has become an important public health problem in China.In recent years,the relationship between uric acid and bone metabolism has gradually attracted the attention of scholars.There have been many in-depth studies on the relationship between uric acid and bone metabolism and mechanisms.In the pathogenesis of osteoporosis,oxidative stress is involved in the modulation and control of osteoblasts and osteoclasts.Uric acid,as an effective antioxidant in the body,affects bone metabolism to a certain extent.Some studies have proposed that uric acid level affects bone metabolism and is correlated with osteoporosis.However,other studies have shown that the relationship between uric acid and osteoporosis is affected by various confounding factors and this relationship is uncertain.Therefore,there are still controversies in previous research conclusions.In this paper,the research progress in the related mechanisms of uric acid and bone metabolism and osteoporosis is reviewed.