GSDMD介导的细胞焦亡在眼科疾病中的研究进展

Advances in research on gasdermin D-mediated pyroptosis in ophthalmology

细胞焦亡是一种新的细胞死亡形式。2015年,gasdermin家族成员gasdermin D(GSDMD)蛋白作为焦亡的关键效应蛋白被发现,并引起了广泛关注。细胞中的GSDMD被激活的caspase-1、caspase-4、caspase-5、caspase-11裂解后,氨基末端转移至细胞膜上寡聚并形成孔隙,允许水分子等物质进入细胞,导致细胞膨胀、破裂从而引发细胞焦亡。本文就GSDMD的结构、作用机制、其与焦亡之间的关系以及GSDMD在眼科疾病中最新的研究进展进行综述,为眼科疾病的治疗提供新思路。

Pyroptosis is a new type of cell death.In 2015,gasdermin D(GSDMD)was discovered as a key effector protein that leads to pyroptosis,attracting much attention.After GSDMD is cleaved by activated caspase-1/-4/-5/-11,the amino terminal oligomerizes and forms pores on the cell membrane,allowing water and other correlative substances to enter the cell,and finally leading to cell swelling,rupturing and then pyroptosis.This paper reviews the GSDMD structure,mechanism,and correlation with pyroptosis,as well as advances in research on the relationship between GSDMD and ophthalmic diseases,providing a new idea for treatment of ophthalmic diseases.