听觉超敏训练联合鼠神经生长因子治疗自闭症患儿的临床效果

Clinical effect of auditory hypersensitivity training combined with Mouse Nerve Growth Factor on autistic children

目的探讨听觉超敏训练联合鼠神经生长因子(mNGF)治疗自闭症患儿临床效果。方法选取2018年6月至2020年12月广东省中山市人民医院收治的201例自闭症患儿作为研究对象,采用随机数字表法将其分为对照组(98例)与观察组(98例)。对照组采用mNGF注射治疗,观察组采用mNGF法联合听觉超敏训练。比较两组干预前及干预后8周的儿童孤独症家长评定心理量表(ABC)、儿童孤独症评定量表评分(CARS)、自闭症评分。采用单因素分析观察组自闭症患儿的干预效果,以观察组自闭症患儿干预前后自闭症总评分差值为因变量,性别、是否独生子女、居住地为自变量进行多因素回归分析。结果两组干预后的ABC评分、CARS评分低于干预前,差异有统计学意义(P<0.05);观察组干预后的ABC评分、CARS评分低于对照组,差异有统计学意义(P<0.05)。两组干预后的各项自闭症评分均高于干预前,差异有统计学意义(P<0.05);且观察组干预后的各项自闭症评分高于对照组,差异有统计学意义(P<0.05)。单因素分析结果显示,观察组不同性别、是否独生子女以及不同居住地患儿的干预前后自闭症总评分差值比较,差异有统计学意义(P<0.05)。多因素分析结果显示,居住地、独生子女与否影响观察组自闭症患儿的干预效果(P<0.05)。结论mNGF结合听觉超敏训练,可显著提高自闭症患儿的治疗效果和各方面能力。且居住地、独生子女与否影响自闭症患儿采用mNGF法联合听觉超敏训练干预的效果。

Objective To investigate the clinical effect of auditory hypersensitivity training combined with Mouse Nerve Growth Factor(mNGF)on autistic children.Methods A total of 201 children with autism admitted to Zhongshan People′s Hospital in Guangdong Province from June 2018 to December 2020 were selected as the research subjects.They were divided into a control group(98 cases)and an observation group(98 cases)by the random number table method.Patients in the control group were treated with mNGF injection,and patients in the observation group were treated with mNGF combined with auditory hypersensitivity training.Before intervention and 8 weeks after intervention,the two groups were compared of the scores of the autism behavior checklist(ABC),childhood autism rating scale(CARS)and autism rating scale.Single factor analysis was used to analyze the effect of intervention on children with autism in the observation group.The difference of total autism score before and after intervention was taken as the dependent variable,and gender,only child or not,and place of residence were taken as the independent variables for multi-factor regression analysis.Results The ABC scores and the CARS scores in the two groups were lower than those before intervention,with statistical significances(P<0.05).The ABC score and the CARS score of the observation group were lower than those of the control group after intervention,with statistical significances(P<0.05).The autism scores of each item in both groups after intervention were higher than those before intervention,with statistical significances(P<0.05).The autism scores of each item of the observation group were higher than those of the control group after intervention,with statistical significances(P<0.05).Univariate analysis showed that there were statistically significant differences in total autism score difference before and after intervention among children of different genders,only children or not,and children of different places of residence in the observation group(P<0.05).The results of multivariate analysis showed that place of residence and only child affected the intervention effect of autistic children in the observation group(P<0.05).Conclusion mNGF combined with auditory hypersensitivity training can significantly improve the therapeutic effect and various abilities of children with autism,and effect of mNGF combined with auditory hypersensitivity training of children with autism was also influenced by the place of residence and the only child or not affect the intervention effect.