基于数据挖掘探究糜烂型口腔扁平苔藓的中药应用规律

Research on application rule of traditional Chinese medicine in erosive oral lichen planus based on data mining

目的运用数据挖掘技术探究中药治疗糜烂型口腔扁平苔藓(EOLP)的组方用药规律。方法检索中国知网、万方、维普期刊全文数据库,以“糜烂型口腔扁平苔藓”“EOLP”“口糜”“中药”等为检索词,检索中药治疗EOLP的相关文献,检索时限为建库至2020年6月。统计分析中药的性味、归经、类别,并进行关联规则及聚类分析。结果共纳入83首中药处方,涉及141味中药。用药频次≥8次的中药共37味,以当归、地黄、甘草、牡丹皮、黄芩多见。归经以肝经居多,药性以寒、甘为主,用药类别以清热凉血药、补虚补气药、清热燥湿药居多。关联分析得到38条支持度较高的中药组合,系统聚类分析共得到6个聚类组。结论中药治疗EOLP以清热解毒、补虚补气、活血化瘀为主,佐以疏肝健脾、滋阴降火,其用药规律可为临床治疗及新药研发提供参考。

Objective To explore the laws of composition and medication of traditional Chinese medicine in the treatment of erosive oral lichen planus(EOLP)based on data mining technology.Methods CNKI,Wanfang and VIP database were retrieved.The relevant literatures on traditional Chinese medicine in the treatment of EOLP were searched with“erosive oral lichen planus”“EOLP”“oral erosion”“Chinese medicine”as retrieval words.The retrieval time limit was from the establishment of each database to June 2020.The nature and taste,meridian and category of traditional Chinese medicine were statistically analyzed,and the association rules and cluster analysis were carried out.Results A total of 83 prescriptions were collected,involving 141 kinds of Chinese medicine.There were 37 kinds of Chinese medicines with medication frequency more than eight times,most of which were Radix Angelicae Sinensis,Radix Rehmanniae Recens,Radix Glycyrrhizae,Cortex Moutan Radicis,Radix Scutellariae.The liver meridian was the main meridian;the main medicinal properties were cold and sweet;most of the drugs were clearing heat and cooling blood drugs,tonifying deficiency and tonifying qi drugs,clearing heat and dispelling dampness drugs.Thirty-eight Chinese medicine combinations with high support were obtained by association analysis,and six cluster groups were obtained by systematic cluster analysis.Conclusion The treatment of EOLP with traditional Chinese medicine mainly focuses on clearing heat and removing toxicity,tonifying deficiency and qi,promoting blood circulation and removing blood stasis,supplemented by soothing liver and invigorating spleen,nourishing yin and reducing fire.Its medication law can provide reference for clinical treatment and new drugs research and development.