摘要
Main observation and conclusion Block copolymers not only combine properties of different segments but also generate new application prospects.Poly(α-amino acid)-b-poly(tetrahydrofuran)-b-poly(α-amino acid)(PAA-PTHF-PAA)is one of the copolymers.In this contribution,di-hydroxyl-ended HO-PTHF-OH is transferred into di-oxyamino-ended H2NO-PTHF-ONH2 quantitatively,which is used as a macroinitiator to polymerize sarcosine N-thiocarboxyanhydride(Sar-NTA)and N-phenyoxycarbonyl N-ε-carbobenzyloxy-D-lysine(ZDL-NPC).Well-defined triblock PAA-NHO-PTHF-ONH-PAA is produced with high molecular weight(up to 25.3 kg/mol)and narrow dispersity.The amphiphilic PSar-NHO-PTHF-ONH-PSar(STS)self-assembles into micelles with uniform diameters of 30—40 nm according to DLS.Owing to oxygen amide groups inside the backbone of these copolymers,the polyether-poly(amino acid)s block copolymers are cleavable under an acidic environment and therefore have potential applications in smart biomedicine and engineering.
基金
supported by the Joint Foundation of Shaanxi Province Natural Science Basic Research Program and Shaanxi Coal Chemical Group Cov Ltd.(No.2019JLM-46)
the National Natural Science Foundation of China(No.21674091).
