异补骨脂素的药理作用和肝肾损伤机制研究进展

Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen

补骨脂是临床常用中药,具有补肾壮阳、固精缩尿的功效。伴随中药补骨脂及其复方制剂使用过程中引起肝脏不良反应的报道日益增多,补骨脂的肝毒性物质基础问题也受到学者的广泛关注。异补骨脂素是中药补骨脂中的主要药效成分和毒性成分。本文主要从药理作用和肝肾毒性2个方面,对2010年至今国内外学者关于异补骨脂素的研究进行综述,为异补骨脂素的新药研究和安全用药提供理论依据。

Psoralea corylifolia is a kind of commonly used traditional Chinese medicine in clinic,which has the effects of tonifying kidney and strengthening Yang,securing essence and reducing urination.Along with the increasing reports of hepatic adverse drug reactions induced by the use of traditional Chinese medicine isopsoralen and its compound preparations,the issue of hepatotoxic substance basis of isopsoralen has also been widely concerned by scholars.Isopsoralen is the main active and toxic component of psoralea corylifolia.This thesis mainly reviews the research on isopsoralen by domestic and foreign scholars from 2010 to now,so as to provide theoretical basis for new drug research and safe use of isopsoralen.