有无精神病史甲基苯丙胺依赖患者的认知功能特征比较

Comparison of cognitive functioning characteristics of methamphetamine addicts with or without a history of psychosis

目的:探讨甲基苯丙胺(methamphetamine,MA)依赖者既往有或无精神病史认知功能特征。方法:本研究通过门诊、住院部及社区招募MA依赖者共53名,其中有过精神病史患者(MAP组)33名,无精神病史患者(MA组)20名,健康对照组(HC组)52名,以计算机化的综合认知测验(CogState量表)测试认知功能,同时收集研究对象一般资料及临床特征。结果:与HC组相比,MAP患者的执行功能明显受损,差异有统计学意义(P=0.002),MA依赖者与其无明显差异(P>0.05);MAP及MA依赖者的社会情绪认知受损,两组与HC组相比,差异有统计学意义(P=0.010,P=0.010)。结论:MA依赖者有过精神病史存在更明显的执行功能缺陷;MAP及MA依赖者均存在社会认知缺陷,在治疗中和康复过程中需重视改善社会认知。

Objective:To study the cognitive functioning characteristics of methamphetamine addicts with or without a history of psychosis.Methods:Fifty-three methamphetamine addicts including 33 with a history of psychosis in methamphetamine addicts(methamphetamine-associated psychosis MAP)and 20 without a history of psychosis in methamphetamine addicts(MA)were enrolled from clinic,inpatient department and community,as well as 52 health controls(HC)enrolled from community.All of them were evaluated cognitive function by the CogState battery.Their demographic data and clinical characteristics were collected.Results:Executive function was significantly impaired in MAP group compared with the HC group,and the difference was statistically significant(P=0.002).MA group were not significantly different from the healthy and MAP groups(P>0.05);Compared to HC group,there was impaired social-emotional cognition in MAP and MA groups,with statistically significant differences(P=0.010,P=0.010).Conclusion:MA addicts with a history of psychosis have more pronounced executive functioning deficits.Both MAP and MA patients have social cognitive deficits and need to pay attention to improving social cognition during treatment and rehabilitation.