摘要
褪黑素是神经内分泌调控的关键激素之一,具有重要的生理功能,在改善睡眠、调节生殖、延缓衰老等生理过程中起到不可或缺的作用,其功能机制研究亦较为成熟。本文综述了褪黑素和褪黑素受体的基本特征,特别关注褪黑素受体介导的信号转导特征;总结了其海洋生物中的褪黑素信号系统研究现状和面临的挑战,并对海洋生物开展该信号系统研究的理论价值及应用前景进行展望,以期为进一步探明海洋鱼类及无脊椎动物中褪黑素及其受体的信号转导特征和生理功能提供一定的线索,为褪黑素信号系统进化演变的探讨提供一定的理论参考。
Melatonin is one of the key hormones in neuroendocrine regulation and has essential physiological func-tions.It plays indispensable roles in improving sleep,regulating reproduction,and delaying aging and other physio-logical processes;moreover,the mechanism regulating its physiological functions has been well studied.This paper mainly reviews the key characteristics of melatonin and its receptors,the receptor-mediated signaling pathway,and the prospects and challenges inherent in melatonin signaling system research in marine organisms.We hope that our work will serve as a valuable reference for studies on melatonin signal transduction,physiological functions,and signaling system evolution in marine animals.
作者
冯佳倩
王天明
杨静文
FENG Jia-qian;WANG Tian-ming;YANG Jing-wen(Marine Science and Technology College,Zhejiang Ocean University,Zhoushan 316022,China;National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources,Zhejiang Ocean University,Zhoushan 316022,China)
出处
《海洋科学》
CAS
CSCD
北大核心
2021年第11期144-155,共12页
Marine Sciences
基金
国家自然科学基金资助项目(41876154,41606150,41406137)
舟山市科技项目(2019C21020)。
关键词
褪黑素
褪黑素受体
信号转导
信号系统
海洋动物
melatonin
melatonin receptor
signal transduction
signal system
marine animals
