琥珀酸亚铁治疗妊娠期合并缺铁性贫血的效果与安全性探讨

Discussion on the effect and safety of ferrous succinate in the treatment of iron-deficiency anemia during pregnancy

目的探讨妊娠期合并缺铁性贫血孕妇采取琥珀酸亚铁进行治疗的临床效果及安全性,旨在为临床医学提供可靠参考依据。方法87例妊娠期合并缺铁性贫血孕妇为研究对象,根据数字表法随机分为治疗组(44例)与对照组(43例)。对照组采取多糖铁复合物胶囊进行治疗,治疗组采取琥珀酸亚铁进行治疗。比较两组孕妇治疗前后的红细胞、血红蛋白、血清铁蛋白水平,治疗效果,不良反应发生情况。结果治疗后,两组孕妇的红细胞、血红蛋白、血清铁蛋白水平均高于本组治疗前,且治疗组孕妇的红细胞(3.86±0.32)×10^(12)/L、血红蛋白(112.43±11.45)g/L、血清铁蛋白(53.25±10.56)μg/L均高于对照组的(3.35±0.23)×10^(12)/L、(102.46±12.56)g/L、(40.35±9.48)μg/L,差异具有统计学意义(P<0.05)。治疗组孕妇的总有效率97.73%高于对照组的86.05%,差异具有统计学意义(P<0.05)。两组孕妇的不良反应发生情况对比,差异无统计学意义(P>0.05)。结论妊娠期合并缺铁性贫血孕妇采取琥珀酸亚铁进行治疗的临床效果显著,可改善孕妇的血清指标,提高治疗效果,且不良反应少,值得临床推广使用。

Objective To discuss the clinical effect and safety of ferrous succinate in the treatment of iron-deficiency anemia during pregnancy,so as to provide reliable reference for clinical medicine.Methods A total of 87 cases of iron-deficiency anemia during pregnancy were studied and randomly divided into treatment group(44 cases)and control group(43 cases)according to random numerical table.The control group was treated with iron polysaccharide complex capsules,and the treatment group was treated with ferrous succinate.Both groups were compared in terms of red blood cell,hemoglobin,and serum ferritin before and after treatment,therapeutic effect,and the occurrence of adverse reactions.Results After treatment,the red blood cell,hemoglobin,and serum ferritin of the two groups were higher than those of this group before treatment,and the red blood cells(3.86±0.32)×10^(12)/L,hemoglobin(112.43±11.45)g/L,and serum ferritin(53.25±10.56)μg/L of the treatment group were higher than(3.35±0.23)×10^(12)/L,(102.46±12.56)g/L,(40.35±9.48)μg/L of the control group.All the differences were statistically significant(P<0.05).The total effective rate 97.73%of the treatment group was higher than 86.05%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ferrous succinate has significane clinical effect on the treatment of iron-deficiency anemia during pregnancy,and it can improve the serum indicators and therapeutic effect with less adverse reactions,which is worthy of clinical promotion and application.