丙硫氧嘧啶和甲巯咪唑治疗甲亢的效果比较

Comparison of the effect of propylthiouracil and thiamazole in the treatment of hyperthyroidism

目的比较分析丙硫氧嘧啶和甲巯咪唑治疗甲状腺功能亢进症(甲亢)的效果。方法60例甲亢患者,随机分为观察组与对照组,每组30例。对照组患者采用丙硫氧嘧啶治疗,观察组患者采用甲巯咪唑治疗。比较两组患者治疗效果,治疗前后甲状腺功能指标[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺激素(FT_(4))促甲状腺激素(TSH)]水平,不良反应发生情况。结果观察组患者治疗总有效率96.67%明显优于对照组的80.00%,差异具有统计学意义(P<0.05)。治疗前,对照组FT_(3)、FT_(4)、TSH分别为(12.09±3.19)pg/ml、(37.51±2.18)ng/ml、(1.19±0.16)mIU/L,与观察组的(12.10±3.16)pg/ml、(37.48±2.13)ng/ml、(1.20±0.17)mIU/L比较差异无统计学意义(P>0.05)。治疗后,两组FT_(3)、FT_(4)、TSH水平均明显优于治疗前,且观察组FT_(3)(3.90±1.12)pg/ml、FT_(4)(10.19±0.22)ng/ml、TSH(1.96±0.20)mIU/L均明显优于对照组的(4.82±1.32)pg/ml、(13.32±0.20)ng/ml、(1.65±0.24)mIU/L,差异具有统计学意义(P<0.05)。观察组不良反应发生率10.00%(3/30)明显低于对照组的33.33%(10/30),差异具有统计学意义(P<0.05)。结论在甲亢治疗中采取甲巯咪唑治疗,相较于丙硫氧嘧啶,其治疗效果更为显著,能够有效改善患者甲状腺功能,减少治疗过程中不良反应发生风险,值得在临床中推广应用。

Objective To compare the effect of propylthiouracil and thiamazole in the treatment of hyperthyroidism.Methods A total of 60 patients with hyperthyroidism were randomly divided into observation group and control group,with 30 cases in each group.Patients in the control group were treated with propylthiouracil,and patients in the observation group were treated with thiamazole.Both groups were compared in terms of therapeutic effect,thyroid function indexes[free triiodothyronine(FT_(3)),free thyroid hormone(FT_(4))thyroid stimulating hormone(TSH)]before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of treatment in the observation group was 96.67%,which was significantly better than 80.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,FT_(3),FT_(4),and TSH of the control group were(12.09±3.19)pg/ml,(37.51±2.18)ng/ml,(1.19±0.16)mIU/L,which were not statistically different from(12.10±3.16)pg/ml,(37.48±2.13)ng/ml,(1.20±0.17)mIU/L of the observation group(P>0.05).After treatment,FT_(3),FT_(4) and TSH in the two groups were significantly better than those of this group before treatment;FT_(3)(3.90±1.12)pg/ml,FT_(4)(10.19±0.22)ng/ml,TSH(1.96±0.20)mIU/L of the observation group were significantly better than(4.82±1.32)pg/ml,(13.32±0.20)ng/ml,(1.65±0.24)mIU/L of the control group;all the differences were statistically significant(P<0.05).The incidence of adverse reactions 10.00%(3/30)in the observation group was significantly lower than 33.33%(10/30)in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with propylthiouracil,thiamazole has more significant effect on the treatment of hyperthyroidism,and it can effectively improve the thyroid function of patients,reduce the risk of adverse reactions during treatment,which is worthy of clinical promotion and application.