麦角新碱联合卡前列素氨丁三醇、缩宫素在胎盘早剥产后大出血中的应用

Application of Ergonovine Combined with Carprost Tromethamine and Oxytocin in the Treatment of Hemorrhage after Placental Abruption

目的对胎盘早剥产后大出血采用麦角新碱联合卡前列素氨丁三醇、缩宫素治疗的效果及对血红蛋白水平的影响进行研究。方法本研究选择了2017年8月至2020年8月之间于深圳市中西医结合医院实施了治疗的84例胎盘早剥产后大出血产妇资料进行分析,将产妇随机分成了对照组(n=42)和观察组(n=42),对照组使用卡前列素氨丁三醇以及缩宫素治疗,观察组在对照组基础上再使用麦角新碱实施治疗,对比两组产妇的第三产程时间、出血时间、各时间段出血量、不良事件出现率以及治疗前后血红蛋白水平。结果对照组第三产程时间和出血时间均高于观察组,组别数据对比有统计学意义(P<0.05).对照组产后15min、30min、60min以及120min出血量显著高于观察组,组别数据对比有统计学意义(P<0.05).对照组不良事件出现率显著高于观察组,组别数据对比有统计学意义(P<0.05)。治疗之前,两组间产妇血红蛋白水平对比无统计学意义(P>0.5);治疗之后,对照组血红蛋白水平低于观察组,组别数据对比有统计学意义(P<0.05)。结论在对胎盘早剥产后大出血产妇实施治疗期间,对其使用麦角新碱联合卡前列素氨丁三醇、缩宫素的治疗方式效果佳,值得推广。

Objective To study the effect of ergonovine combined with carprost tromethamine and oxytocin on massive hemorrhage after placental abruption and its influence on hemoglobin level.Methods This study selected 84 cases of massive hemorrhage after placental abruption who were treated in our hospital between August 2017 and August 2020 for analysis.The women were randomly divided into a control group(n=42)and an observation group(n=42),the control group was treated with carboprost tromethamine and oxytocin,and the observation group was treated with ergonovine on the basis of the control group.The third stage of labor time,bleeding time,each Bleeding volume,incidence of adverse events,and hemoglobin levels before and after treatment.Results The third stage of labor time and bleeding time in the control group were higher than those in the observation group,and the comparison of group data was meaningful(P<0.05).The blood loss at 15 minutes,30 minutes,60 minutes and 120 minutes after delivery in the control group was significantly higher than that in the observation group,and the comparison of group data was meaningful(P<0.05).The incidence of adverse events in the control group was significantly higher than that in the observation group,and the comparison of group data was meaningful(P<0.05).Before treatment,the comparison of maternal hemoglobin levels between the two groups was meaningless(P>0.5);after treatment,the hemoglobin level of the control group was lower than that of the observation group,and the comparison of group data was meaningful(P<0.05).Conclusion During the period of treatment for women with massive hemorrhage after placental abruption,the treatment of ergonovine combined with carprost tromethamine and oxytocin is effective and is worthy of promotion.