亚麻量丙泊酚对妇科腹腔镜手术后恶心呕吐的影响

The effect of sub-anesthetic dose propofol on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery

目的探讨亚麻醉剂量丙泊酚对妇科腹腔镜手术患者术后恶心呕吐的影响。方法选择ASA分级Ⅰ~Ⅱ级的妇科腹腔镜手术患者320例,随机分为实验组160例和对照组160例,实验组在手术结束撤腹腔镜时静脉注入丙泊酚0.4mg/kg,对照组在撤腹腔镜时静脉注入0.9%氯化钠注射液5ml,观察各组术后24h内的恶心呕吐的发生率。结果实验组在术后4h以内恶心呕吐的发生率明显低于对照组(P<0.05),术后4~24h期间恶心呕吐的发生率则无明显差异(P>0.05)。结论亚麻醉剂量丙泊酚可以降低妇科腹腔镜手术术后早期恶心呕吐的发生率。

Objective To investigate the effect of Sub-anesthetic dose of propofol on postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery.Methods Three hundred and twenty ASAⅠ~Ⅱpatients undergoing gynecological laparoscopic surgery were randomly divided into experimental group(n=160)and control group(n=160).In the experimental group,propofol 0.4mg/kg was intravenously injected at the end of the operation,a nd controls were intravenously injected 5ml of 0.9%sodium chloride at the same time.The incidence of nausea and vomiting within 24h after operation was observed in each group.Results The incidence of nausea and vomiting in the experimental group within 4 hours after operation was significantly lower than that in the control group(P<0.05),but there was no significant difference in the incidence of nausea and vomiting between 4~24 hours after operation(P>0.05).Conclusion Sub-anesthetic dose of propofol can reduce the incidence of nausea and vomiting in the early stage after gynecological laparoscopic surgery.