脑梗死患者血清sdLDL,GSH-Px,Hcy及SDF-1水平与血管狭窄的相关性研究

Study on the Correlation between Serum sdLDL,GSH-Px,Hcy and SDF-1 Levels and Vascular Stenosis in Patients with Cerebral Infarction

目的研究脑梗死患者血清中小而密低密度脂蛋白(sdLDL)、谷胱甘肽过氧化物酶(GSH-Px)、同型半胱氨酸(Hcy)及基质细胞衍生因子1(SDF-1)水平与血管狭窄的关系。方法选取2018年1月~2020年5月期间宁德师范学院附属宁德市医院收治的120例脑梗死患者作为研究对象,按照有无血管狭窄分为狭窄组患者50例(轻度狭窄患者14例,中度狭窄患者16例,重度狭窄患者20例)和非狭窄组70例,另选取同期健康体检120例志愿者作为对照组,分析观察组与对照组、狭窄组与非狭窄组、不同狭窄程度的sdLDL,GSH-Px,Hcy及SDF-1水平之间的差异,研究血清sdLDL,GSH-Px,Hcy及SDF-1水平与脑梗死患者血管狭窄的相关性。结果观察组患者的sdLDL,Hcy,SDF-1水平显著高于对照组(t=21.492,36.909,69.163,均P<0.05),GSH-Px水平显著低于对照组(t=11.190,P<0.05),差异均有统计学意义。狭窄组患者的sdLDL,SDF-1,Hcy水平显著高于非狭窄组(t=3.862,6.417,9.337,均P<0.05),GSH-Px水平显著低于非狭窄组(t=10.873,P<0.05),差异均有统计学意义。通过两两比较,三组患者的sdLDL(t=2.394~4.675,均P<0.05),SDF-1(t=4.111~9.112,均P<0.05),Hcy(t=2.346~5.938,均P<0.05)从高到低依次为重度组、中度组和轻度组,GSH-Px从高到低依次为轻度组、中度组和重度组(t=2.622~11.484,均P<0.05),差异均有统计学意义。Spearman相关性分析显示,患者的Hcy,sdLDL,SDF-1与血管狭窄程度呈正相关(r=0.334,0.526,0.741,均P<0.05),患者的GSH-Px与血管的狭窄程度呈负相关(r=-0.441,P<0.05)。结论血清sdLDL,GSH-Px,Hcy和SDF-1水平与脑梗死患者血管狭窄呈显著相关性,可为临床的诊断提供重要依据。

Objective To study the relationship between serum levels of sdLDL,GSH-Px and SDF-1 and vascular stenosis in patients with cerebral infarction.Methods 120 patients with cerebral infarction treated in Ningde Hospital Affiliated to Ningde Normal University from January 2018 to May 2020 were selected as the research objects.According to the presence or absence of vascular stenosis,they were divided into 50 patients in the stenosis group(14 patients with mild stenosis,16 patients with moderate stenosis and 20 patients with severe stenosis)and 79 patients in the non stenosis group.In addition,120 healthy volunteers in the same period were selected as the control group.The differences of sdLDL,GSH-Px,Hcy and SDF-1 levels between observation group and control group,stenosis group and non stenosis group,and different degrees of stenosis were analyzed to study the correlation between serum sdLDL,GSH-Px,Hcy and SDF-1 levels and vascular stenosis in patients with cerebral infarction.Results The levels of sdLDL,Hcy and SDF-1 in observation group were significantly higher than those in control group(t=21.492,36.909,69.163,all P<0.05),while the level of GSH-Px in observation group was significantly lower than that in control group(t=11.190,P<0.05),with statistical significance.The levels of sdLDL,SDF-1 and Hcy in the stenosis group were significantly higher than those in the non-stenosis group(t=3.862,6.417,9.337,all P<0.05),and the level of GSH-Px was significantly lower than that in the non-stenosis group(t=10.873,P<0.05),with statistically significant differences.By pairings comparison,sdLDL(t=2.394~4.675,all P<0.05),SDF-1(t=4.111~9.112,all P<0.05),Hcy(t=2.346~5.938,all P<0.05)from high to low were severe group,moderate group and mild group,GSH-Px from high to low were mild group,moderate group and severe group(t=2.622~11.484,all P<0.05),the differences were statistically significant.Spearman correlation analysis showed that sdLDL,SDF-1 and Hcy were positively correlated with the degree of vascular stenosis(r=0.334,0.526,0.741,all P<0.05),while GSH-Px was negatively correlated with the degree of vascular stenosis(r=-0.441,P<0.05).Conclusion Serum sdLDL,GSH-Px and SDF-1 levels were significantly correlated with vascular stenosis in patients with cerebral infarction,which can be used as an important basis for clinical diagnosis in the future.