临床患者血清CK-MB活性大于总肌酸激酶活性的生物学特征及原因分析

Biological Characteristics and Cause Analysis of Clinical Patients with Serum CK-MB-to-Total-CK Ratio More Than 1.0

目的回顾性分析血清肌酸激酶同工酶(creatine kinase-MB,CK-MB)活性大于总肌酸激酶(creatine kinase,CK)活性的患者生物学特征及其原因。方法选取2017~2018年陕西省人民医院住院部29993例住院患者为研究对象,使用全自动生化分析仪速率法检测血清CK活性和免疫抑制法检测血清CK-MB活性,用统计学方法分析CK-MB>CK患者的生物学特征及产生的原因。结果在29993例患者中血清CK-MB>CK占0.81%(242/29993)。总体上在各年龄段中血清CK-MB>CK患者人数差异有统计学意义(χ^(2)=60.626,P=0.000),而且在各年龄段之间血清CK-MB>CK的男性和女性患者人数差异均有统计学意义(χ^(2)=24.787,46.206,均P=0.000);<15岁患者中血清CK-MB>MB人数最多。血清CK-MB>CK男性患者人数少于女性患者人数(45.87%vs 54.13%),差异具有统计学意义(χ^(2)=13.099,P=0.022),其中15~30岁组男性患者人数明显少于女性患者,差异有统计学意义(χ^(2)=6.962,P=0.008),其他年龄段男女患者人数差异无统计学意义(χ^(2)=0.249~3.931,均P>0.05)。血清CK-MB>CK患者所患疾病中,感染性疾病占44.2%(107/242),恶性肿瘤占20.7%(50/242),其他疾病共占35.1%(85/242)。结论明确血清CK-MB>CK患者生物学特征及与所患疾病的关系,有助于临床鉴别诊断相关疾病。

Objective Retrospective analysis on biological characteristics of patients with serum CK-MB-to-total-CK ratio more than 1.0(CK-MB>CK)was performed.Methods 29993 patients were recruited from inpatient departments of Shaanxi Provincial Hospital from January 2017 to December 2018.Serum CK activity and CK-MB activity were detected by automatic biochemical analyzer with rate method and immunosuppression methods,respectively.Results The patients with serum CKMB>CK accounted for 0.81%(242/29993).Generally,there existed statistical differences for the number of patients with serum CK-MB>CK between age groups(χ^(2)=60.626,P=0.000).There existed significantly statistical difference between age groups for male patients with serum CK-MB>CK(χ^(2)=24.787,P=0.000)as well as female ones(χ^(2)=46.206,P=0.000).There were the most male patients with CK-MB>CK younger than 15 years old as well as female ones(45.87%vs 54.13%).The male patients with CK-MB>CK was statistically less than that of female ones,the difference was significantly statistical(χ^(2)=13.099,P=0.022).The female patients aged from 10 to 15 years old with CK-MB>CK were more than those of male ones(χ^(2)=6.962,P=0.008)and there were no statistical differences between other age groups(χ^(2)=0.249~3.931,all P>0.05).44.2%(107/242)of patients with serum CK-MB>CK had infectious diseases,20.7%(50/242)malignant tumors and 35.1%(85/242)other diseases.Conclusion The investigation was helpful for further understanding biological characteristics of patients with serum CK-MB>CK and clinical differential diagnosis.