基于治疗性生活方式干预对双相情感障碍患者糖脂代谢的临床研究

Clinical research on glucose and lipid metabolisms in patients with bipolar affective disorder based on therapeutic lifestyle changes

目的观察治疗性生活方式干预(TLC)对双相情感障碍患者糖脂代谢的影响。方法将80例双相情感障碍患者分为研究组与对照组,每组各40例,两组患者在入组后均接受12周的药物治疗。研究组采用治疗性生活方式干预,对照组采用常规健康宣教活动。观察12周,评定两组治疗前后的体重指数(BMI)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖水平。结果两组的BMI指数、空腹血糖、TC、TG、HDL-C、LDL-C比较,差异无统计学意义(P>0.05)。治疗12周后,研究组的BMI、空腹血糖、TG分别为(21.47±0.67)kg/m^(2)、(4.87±0.36)mmol/L、(4.67±0.25)mmol/L,明显低于对照组的(24.84±1.68)kg/m^(2)、(6.23±0.28)mmol/L、(6.09±0.54)mmol/L,差异有统计学意义(P<0.05)。两组的TC、HDL-C和LDL-C比较,差异无统计学意义(P>0.05)。结论基于治疗性生活方式干预可改善双相情感障碍患者糖脂代谢,值得临床应用。

Objective To observe the impacts of therapeutic lifestyle changes(TLC)on glucose and lipid metabolisms in patients with bipolar affective disorder.Methods A total of 80 patients with bipolar affective disorder were divided into the study group(n=40)and the control group(n=40).Both groups were given drug treatment for 12 weeks after admitted to the group.The study group was intervened by TLC,while the control group was treated with conventional health education.After 12 weeks of observation,the body weight,body mass index(BMI),blood pressure,triglyceride(TG),cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and fasting blood glucose levels of the two groups were evaluated before and after treatment.Results There were no statistically significant differences in the BMI index,fasting blood glucose,TC,TG,HDL-C and LDL-C between the study group and the control group(P>0.05).After 12 weeks of treatment,the BMI,the fasting blood glucose and TG in the study group was(21.47±0.67)kg/m^(2),(4.87±0.36)mmol/L,(4.67±0.25)mmol/L,which were lower than those of(24.84±1.68)kg/m^(2),(6.23±0.28)mmol/L,(6.09±0.54)mmol/L in the control group,with statistically significant difference(P<0.05).There were no statistically significant differences in the TC,HDL-C and LDL-C between the study group and the control group(P>0.05).Conclusion Intervention based on TLC can improve glucose and lipid metabolisms in patients with bipolar affective disorder,which is worthy of clinical application.