植物黄酮调控JNK通路干预氧化应激相关疾病的研究进展

Research Progress of Plant Flavonoids Regulating JNK Signal Pathway to Intervene with Oxidative Stress-related Diseases

c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)是丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)家族的成员。JNK信号传导途径由一系列激酶调节,参与细胞增殖、分化、凋亡、神经元功能和应激反应等生理功能的调控,介导多种疾病的发生。植物膳食中的黄酮类化合物具有抗氧化、抗炎、调节血管渗透等能力,可以通过调控氧化应激反应对JNK相关的疾病产生显著的干预效果。本文介绍了植物黄酮通过调控JNK通路干预氧化应激相关疾病的研究进展,为今后的研究和应用提供借鉴。

c-Jun N-terminal kinase(c-Jun N-terminal kinase, JNK) is a member of the mitogen-activated protein kinase(mitogen-activated protein kinase, MAPK) family. This signal transduction pathway is regulated by a series of kinases and participates in the regulation of physiological functions such as cell proliferation, differentiation, apoptosis, neuronal function and stress response, and mediates the occurrence of many diseases. Flavonoids in plant diets have the ability to resist oxidation, anti-inflammatory, and regulate vascular penetration, and can produce significant intervention effects on JNK-related diseases by regulating oxidative stress. This article introduces the research progress of plant flavonoids intervening oxidative stress-related diseases by regulating the JNK pathway, and provides reference for future research and application.